The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems
The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems
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DOI：
10.1007/s00221-003-1608-0
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发表时间：
2003-12-01
影响因子：
2
通讯作者：
Edeline, JM
中科院分区：
文献类型：
--
作者：
Edeline, JM
本次审查的目的是双重的。首先，它的目的是描述不断塑造未用药动物丘脑皮质感觉系统中的感受野（RF）和地图的动态调节。其次，它旨在讨论行为神经科学和感觉生理学之间尚未解决的几个重要问题。第一部分介绍了当未用药的动物自发地从清醒状态转变为慢波睡眠或矛盾睡眠（也称为快速眼动睡眠）时观察到的射频调制。第二部分表明，与第一部分中描述的一般变化相反，行为训练可以产生选择性效应，有利于在学习过程中获得意义的刺激。第三部分回顾了丘脑皮质系统的两种主要神经调节剂——乙酰胆碱和去甲肾上腺素——所引发的影响，这两种调节剂传统上与警觉状态的转换和学习经历有关。结论认为，由于清醒动物的感受野和地图每时每刻都在不断调节，学习引起的感觉可塑性可以被视为多种可能状态之一的感受野和地图的“结晶”。研究神经调节剂之间的相互作用可以帮助理解这种动态调节的神经生物学基础。
The goal of this review is twofold. First, it aims to describe the dynamic regulation that constantly shapes the receptive fields (RFs) and maps in the thalamo-cortical sensory systems of undrugged animals. Second, it aims to discuss several important issues that remain unresolved at the intersection between behavioral neurosciences and sensory physiology. A first section presents the RF modulations observed when an undrugged animal spontaneously shifts from waking to slow-wave sleep or to paradoxical sleep (also called REM sleep). A second section shows that, in contrast with the general changes described in the first section, behavioral training can induce selective effects which favor the stimulus that has acquired significance during learning. A third section reviews the effects triggered by two major neuromodulators of the thalamo-cortical system-acetylcholine and noradrenaline-which are traditionally involved both in the switch of vigilance states and in learning experiences. The conclusion argues that because the receptive fields and maps of an awake animal are continuously modulated from minute to minute, learning-induced sensory plasticity can be viewed as a 'crystallization' of the receptive fields and maps in one of the multiple possible states. Studying the interplays between neuromodulators can help understanding the neurobiological foundations of this dynamic regulation.