Neighborhood crime and depressive symptoms among African American women: Genetic moderation and epigenetic mediation of effects.
Neighborhood crime and depressive symptoms among African American women: Genetic moderation and epigenetic mediation of effects.
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DOI：
10.1016/j.socscimed.2015.10.035
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Philibert RA
中科院分区：
文献类型：
--
作者：
Lei MK;Beach SR;Simons RL;Philibert RA
社会科学家早就认识到邻里犯罪在压力相关疾病中的重要作用，但对可能将生活在高犯罪率社区的经历与抑郁症联系起来的潜在生物社会机制知之甚少。目前的研究介绍了一个综合模型，结合邻里，遗传和表观遗传因素。假设进行了测试，99个非裔美国妇女的家庭和社区健康研究（FACHS）的样本。5-羟色胺转运体基因（5-HTT）的等位基因变体与邻里犯罪相互作用，以符合差异易感性观点的方式预测抑郁症状。此外，这种关联是由5-羟色胺转运蛋白基因启动子区的DNA甲基化介导的。这些发现为一个综合模型提供了支持，在该模型中，由邻里犯罪引起的DNA甲基化的变化可能导致基因活性的增加或减少，从而影响抑郁症状。
Social scientists have long recognized the important role that neighborhood crime can play in stress-related disease, but very little is known about potential biosocial mechanisms that may link the experience of living in high-crime neighborhoods with depression. The current study introduces an integrated model that combines neighborhood, genetic, and epigenetic factors. Hypotheses were tested with a sample of 99 African American women from the Family and Community Health Study (FACHS). Allele variants of the serotonin transporter gene (5-HTT) interact with neighborhood crime to predict depressive symptoms in a manner consonant with the differential susceptibility perspective. Furthermore, this association is mediated by DNA methylation of the promoter region of the serotonin transporter gene. The findings provide support for an integrated model in which changes in DNA methylation, resulting from neighborhood crime, can result in an increase or decrease in gene activity which, in turn, influences depressive symptoms.