Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma: risk factors and patterns
Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma: risk factors and patterns
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DOI：
10.1007/s00535-007-2123-z
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发表时间：
2008-01-01
影响因子：
6.3
通讯作者：
Saigenji, Katsunori
中科院分区：
文献类型：
--
作者：
Okuwaki, Yusuke;Nakazawa, Takahide;Saigenji, Katsunori
背景资料。肝细胞癌手术切除或局部消融治疗后频繁肝内复发的发病机制尚不清楚。研究射频消融后单个原发肝细胞癌病灶发生肝内远端复发的风险和模式。方法：研究方法。90名原发灶直径小于3厘米的肝癌患者接受了完全射频消融。分析IDR的危险因素及射频消融后IDR的类型。结果。中位随访期为37.4个月。44例(48.9%)患者出现IDR。1、3、5年IDR累积率分别为10.4%、52.5%、77.0%。单因素分析显示，治疗前血清甲胎蛋白水平为50 ng/ml(P=0.0324)，去甲氧基凝血酶原水平为40mAu/ml(P=0.006)。
Background. The pathogenesis of frequent intrahepatic recurrence of hepatocellular carcinoma (HCC) after surgical resection or local ablation therapy remains uncertain. Risks and patterns of intrahepatic distant recurrence (IDR) of a single, primary HCC lesion after radiofrequency (RF) ablation were examined. Methods. Ninety patients with a single primary HCC lesion of less than 3 cm who had complete RF ablation were enrolled in the study. Risk factors for IDR and the patterns of IDR after RF ablation were analyzed. Results. The median follow-up was 37.4 months. IDR was observed in 44 (48.9%) patients. The cumulative rate of IDR was 10.4%, 52.5%, and 77.0% at 1, 3, and 5 years, respectively. Univariate analysis revealed that a pretreatment serum alpha-fetoprotein (AFP) level of >= 50ng/ml (P = 0.0324), a des-gamma-carboxy prothrombin (DCP) level of >= 40mAu/ml (P = 0.006), an ablative margin of