Schizophrenic Patients and Their Unaffected Siblings Share Increased Resting-State Connectivity in the Task-Negative Network but Not Its Anticorrelated Task-Positive Network
Schizophrenic Patients and Their Unaffected Siblings Share Increased Resting-State Connectivity in the Task-Negative Network but Not Its Anticorrelated Task-Positive Network
复制标题
精神分裂症患者及其未受影响的兄弟姐妹在任务消极网络中的静息态连接性增加，但其反相关任务积极网络则不然
DOI：
10.1093/schbul/sbq074
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发表时间：
2012-03-01
影响因子：
6.6
通讯作者：
Liu, Zhening
中科院分区：
文献类型：
--
作者：
Liu, Haihong;Kaneko, Yoshio;Liu, Zhening
精神分裂症与反相关内在网络、任务负向网络(TNN)和任务正向网络(TPN)的连接异常有关。精神分裂症患者和他们未受影响的兄弟姐妹之间的比较有助于进一步了解疾病易感性和病理生理学。我们检测了精神分裂症患者、他们未受影响的同胞和健康对照组之间内在网络中静息状态连接性的差异。每组受试者中有25人获得了静态功能磁共振图像。以扣带回后叶/楔前叶和右侧背外侧前额叶皮质为种子区，通过功能连接性分析识别TNN和TPN。利用所有受试者共同区域组成的重叠内在网络分析区域间的连通性强度。精神分裂症患者和他们未受影响的兄弟姐妹在双侧颞下回之间的TNN连通性增加。相比之下，仅精神分裂症患者在三叉神经核扣带后皮质/楔前叶和左下颞回之间以及腹侧前额叶皮质和右侧顶叶皮质之间的连接性增强。精神分裂症患者左侧背外侧前额叶皮质和右侧额叶下回之间的连通性较正常同胞增强，但这一趋势仅与健康对照组相比具有统计学意义。内在网络的重新状态高连通性可能扰乱网络协调，从而参与精神分裂症的病理生理学。类似的，尽管程度较轻，精神分裂症患者未受影响的兄弟姐妹的TNN的高连接性可能有助于精神分裂症内表型的识别，并最终有助于精神分裂症危险基因的确定。
Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls.Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups.Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls.Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.