Harvard report on cancer prevention volume 4: Harvard Cancer Risk Index
Harvard report on cancer prevention volume 4: Harvard Cancer Risk Index
复制标题
DOI：
10.1023/a:1008984432272
复制
发表时间：
2000-07-01
影响因子：
2.3
通讯作者：
Hunter, DJ
中科院分区：
文献类型：
--
作者：
Colditz, GA;Atwood, KA;Hunter, DJ
目的：癌症风险预测是目前健康风险评估的一个次要组成部分。对个体癌症风险的认识很差。一个癌症风险指数的发展，以预测个人癌症的风险占80%的癌症负担在美国。方法：我们使用的研究人员在哈佛医学院和哈佛公共卫生学院的群体共识，以确定明确的，可能的和可能的癌症原因的风险因素。根据因果关系的强度分配风险点并求和。从SEER数据中获得人群平均癌症风险和累积10年风险。确定相对于群体平均值的个体排名。在前瞻性队列data.Results：结肠癌发病率的有效性评估的风险指数：哈佛癌症风险指数提供了一个广泛的癌症风险分类。对队列数据的验证显示良好的协议结肠cancer.Conclusion：哈佛癌症风险指数提供了一个简单的个人癌症风险估计。它可能有助于告知用户癌症的主要风险因素，并确定生活方式的变化，这将降低他们的风险。它提供了有针对性的健康促进信息的潜力。
Objective: Prediction of cancer risk is a minor component of current health risk appraisals. Perception of individual cancer risk is poor. A Cancer Risk Index was developed to predict individual cancer risk for cancers accounting for 80% of the cancer burden in the United States.Methods: We used group consensus among researchers at the Harvard Medical School and Harvard School of Public Health to identify risk factors as definite, probable and possible causes of cancer. Risk points were allocated according to the strength of the causal association and summed. Population average risk of cancer and cumulative 10-year risk was obtained from SEER data. Individual ranking relative to the population average was determined. The risk index was evaluated for validity using colon cancer incidence in prospective cohort data.Results: The Harvard Cancer Risk Index provides a broad classification of cancer risk. Validation against cohort data shows good agreement for colon cancer.Conclusion: The Harvard Cancer Risk Index offers a simple estimation of personal risk of cancer. It may help inform users of the major risk factors for cancer and identify changes in lifestyle that will reduce their risk. It offers the potential for tailored health-promotion messages.