Cerebellar lobules and dentate nuclei mirror cortical force-related-BOLD responses: Beyond all (linear) expectations.
Cerebellar lobules and dentate nuclei mirror cortical force-related-BOLD responses: Beyond all (linear) expectations.
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DOI：
10.1002/hbm.23541
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发表时间：
2017-05
影响因子：
4.8
通讯作者：
Gandini Wheeler-Kingshott CA
中科院分区：
文献类型：
--
作者：
Alahmadi AA;Pardini M;Samson RS;Friston KJ;Toosy AT;D'Angelo E;Gandini Wheeler-Kingshott CA
BOLD反应和施加的力之间的关系进行了量化，在小脑中使用的权力握任务。为了研究小脑是否以开/关的方式响应运动需求或以参数化的方式对运动响应做出贡献，类似于皮质，在视觉反馈下研究了五个握力水平。在13名健康志愿者中采集了功能性MRI数据，并使用小脑优化的管道分析了他们的反应。这使我们能够在小脑内评估小脑激活和力之间的体素线性和非线性关联。我们显示了广泛的非线性激活（参数设计），覆盖小脑的前叶和后叶，并具有区域依赖性的BOLD-力关系。线性反应主要位于前叶，类似于皮质，其中线性反应位于M1。复杂的反应被定位在后叶，反映了其在注意力和执行过程中的关键作用，需要在视觉引导运动。考虑到小脑皮层的高度组织化反应，一个关键问题是小脑深部核团是否表现出类似的参数效应。我们发现，正相关与力在同侧齿状核和对侧的负相关，这表明齿状核的组织与小脑和皮质区。我们的研究结果证实，有小脑组织，涉及所有的灰质结构，反映功能分离的皮质，小脑小叶和齿状核有助于复杂的运动任务与不同的BOLD响应配置文件的力量。脑地图38：2566-2579，2017。© 2017 Wiley Periodicals，Inc.
The relationship between the BOLD response and an applied force was quantified in the cerebellum using a power grip task. To investigate whether the cerebellum responds in an on/off way to motor demands or contributes to motor responses in a parametric fashion, similarly to the cortex, five grip force levels were investigated under visual feedback. Functional MRI data were acquired in 13 healthy volunteers and their responses were analyzed using a cerebellum‐optimized pipeline. This allowed us to evaluate, within the cerebellum, voxelwise linear and non‐linear associations between cerebellar activations and forces. We showed extensive non‐linear activations (with a parametric design), covering the anterior and posterior lobes of the cerebellum with a BOLD‐force relationship that is region‐dependent. Linear responses were mainly located in the anterior lobe, similarly to the cortex, where linear responses are localized in M1. Complex responses were localized in the posterior lobe, reflecting its key role in attention and executive processing, required during visually guided movement. Given the highly organized responses in the cerebellar cortex, a key question is whether deep cerebellar nuclei show similar parametric effects. We found positive correlations with force in the ipsilateral dentate nucleus and negative correlations on the contralateral side, suggesting a somatotopic organization of the dentate nucleus in line with cerebellar and cortical areas. Our results confirm that there is cerebellar organization involving all grey matter structures that reflect functional segregation in the cortex, where cerebellar lobules and dentate nuclei contribute to complex motor tasks with different BOLD response profiles in relation to the forces. Hum Brain Mapp 38:2566–2579, 2017. © 2017 Wiley Periodicals, Inc.