Vgamma9Vdelta2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates.
Vgamma9Vdelta2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates.
复制标题
DOI：
10.1038/cmi.2012.78
复制
发表时间：
2013-05-01
影响因子：
24.1
通讯作者：
Mao, Meng
中科院分区：
文献类型：
--
作者：
Li, Jinrong;Li, Hong;Mao, Meng
早产儿和小于胎龄儿（SGA）是易受各种微生物感染的弱势群体。V γ 9 V δ 2-T细胞是宿主免疫系统的关键组分，并且已被证明在成人中防御病毒感染中发挥重要作用。然而，儿童，特别是早产儿和SGA人群中Vgamma 9Vdelta 2-T细胞的特征知之甚少。在这里，我们检查了新生儿（包括早产儿、SGA和足月婴儿）中Vgamma 9Vdelta 2-T细胞的频率和抗病毒功能。与成人相比，新生儿血液中V γ 9 V δ 2-T细胞的百分比显著较低。在流感病毒刺激后，新生儿Vgamma 9Vdelta 2-T细胞，特别是早产儿和SGA婴儿，显示出比成人明显减少和延迟的抗病毒细胞因子反应。此外，新生儿Vgamma 9Vdelta 2-T细胞的抗病毒反应与胎龄和出生体重呈正相关。最后，新生儿中异戊烯焦磷酸（IPP）引起的Vgamma 9Vdelta 2-T细胞扩增比成人中的扩增弱。我们的数据表明，抗病毒活性降低和Vgamma 9Vdelta 2-T细胞频率降低可能是新生儿，特别是早产儿和SGA婴儿对微生物感染的高易感性的原因。提高新生儿V γ 9V δ 2-T细胞功能可能为抗病毒感染提供新的途径。
Preterm and small-for-gestational-age (SGA) neonates are vulnerable groups that are susceptible to various microbial infections. Vgamma9Vdelta2-T cells are critical components of the host immune system and have been demonstrated to play an important role in the defense against viral infection in adults. However, the characteristics of Vgamma9Vdelta2-T cells in children, especially the preterm and SGA populations, are poorly understood. Here, we examined the frequency and antiviral function of Vgamma9Vdelta2-T cells in neonates, including preterm, SGA and full-term babies. When compared to adults, neonates had a significantly lower percentage of Vgamma9Vdelta2-T cells in the blood. Upon influenza virus stimulation, neonatal Vgamma9Vdelta2-T cells, especially from preterm and SGA babies, showed markedly decreased and delayed antiviral cytokine responses than those of adults. In addition, the antiviral responses of neonatal Vgamma9Vdelta2-T cells were positively correlated with gestational age and birth weight. Finally, a weaker expansion of Vgamma9Vdelta2-T cells by isopentenyl pyrophosphate (IPP) was shown in neonates than the expansion in adults. Our data suggest that the depressed antiviral activity and decreased frequency of Vgamma9Vdelta2-T cells may likely account for the high susceptibility to microbial infection in neonates, particularly in preterm and SGA babies. Improving Vgamma9Vdelta2-T-cell function of neonates may provide a new way to defend against virus infection.