A rhesus monkey mode of self-injury: Effects of relocation stress on behavior and neuroendocrine function
A rhesus monkey mode of self-injury: Effects of relocation stress on behavior and neuroendocrine function
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DOI：
10.1016/j.biopsych.2007.10.025
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发表时间：
2008-05-15
影响因子：
10.6
通讯作者：
Meyer, Jerrold S.
中科院分区：
文献类型：
--
作者：
Davenport, Matthew D.;Lutz, Corrine K.;Meyer, Jerrold S.
背景：自伤行为(SIB)是一种在临床和非临床人群中困扰许多人的障碍，已被认为与高度应激和唤醒状态有关。然而，没有发表关于压力增加和SIB发生率变化之间关系的纵向数据。本研究观察了SIB猕猴和对照猕猴对搬迁应激的短期和长期行为和神经内分泌反应。方法：在新建的设施中，20只成年雄性恒河猴暴露在搬迁到新的住房安排的应激中。观察搬家前后动物的日间行为、睡眠和下丘脑-垂体-肾上腺皮质(HPA)轴功能的多项指标。结果：搬迁导致动物出现复杂的短期和长期影响模式。SIB动物表现出自咬行为的长期增加，以及睡眠障碍的证据。两组都表现出唾液、血清和毛发中皮质醇水平的升高，以及循环中皮质类固醇结合球蛋白(CBG)浓度的意外延迟增加。结论：我们的结果表明，重新安置是猕猴的一个重要应激源，这种应激源触发了先前被认为患有SIB的猕猴自咬行为和睡眠障碍的增加。这些发现表明，生活压力可能同样会加剧患有这种疾病的人类的SIB。HPA轴的结果强调了CBG在调节对主要应激源的长期神经内分泌反应中的潜在作用。
Background: Self-injurious behavior (SIB), a disorder that afflicts many individuals within both clinical and nonclinical populations, has been linked to states of heightened stress and arousal. However, there are no published longitudinal data on the relationship between increases in stress and changes in the incidence of SIB. This study investigated the short- and long-term behavioral and neuroendocrine responses of SIB and control monkeys to the stress of relocation.Methods: Twenty adult male rhesus macaques were exposed to the stress of relocation to a new housing arrangement in a newly constructed facility. Daytime behavior, sleep, and multiple measures of hypothalamic-pituitary-adrenocortical (HPA) axis function were investigated before and after the move.Results: Relocation induced a complex pattern of short- and long-term effects in the animals. The SIB animals showed a long-lasting increase in self-biting behavior, as well as evidence of sleep disturbance. Both groups exhibited elevated cortisol levels in saliva, serum, and hair, and also an unexpected delayed increase in circulating concentrations of corticosteroid binding globulin (CBG).Conclusions: Our results indicate that relocation is a significant stressor for rhesus macaques and that this stressor triggers an increase in self-biting behavior as well as sleep disturbance in monkeys previously identified as suffering from SIB. These findings suggest that life stresses may similarly exacerbate SIB in humans with this disorder. The HPA axis results underscore the potential role of CBG in regulating long-term neuroendocrine responses to major stressors.