Computerized reaction time battery versus a traditional neuropsychological battery:: Detecting HIV-related impairments
Computerized reaction time battery versus a traditional neuropsychological battery:: Detecting HIV-related impairments
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DOI：
10.1017/s1355617703910071
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Gonzalez, R;Heaton, RK;Grant, I
近年来，使用计算机神经心理学（NP）评估措施的兴趣有所增加。然而，关于这些指标的性能与更传统的临床工具的性能之间的关系，数据有限。在本研究中，82名HIV阳性男性，他们都被认为在临床上有神经行为障碍。完成了传统的NP电池（TNB）和加州计算机化评估包（CalCAP，计算机化反应时间测试的集合）。基于TNB的总分以及基于CalCAP的总分均与免疫抑制程度（CD4计数）和脑脊液中可检测的病毒载量显著相关，但与血浆中可检测的病毒载量无关。TNB和CalCAP组合的既定标准分别将57%和49%的HIV+样本分类为受损。当使用TNB作为“金标准”时，基于CalCAP汇总评分的损伤分类显示出68%的灵敏度和77%的特异性。电池之间损伤分类的总体一致性较低（kappa =.44）。这项研究的数据表明，传统的NP电池和计算机化的反应时间测试不测量相同的东西，并且在检查HIV相关的NP损伤时不可互换。
In recent years, interest in the use of computerized neuropsychological (NP) assessment measures has increased. However, there are limited data regarding how performance on these measures relates to performance on more traditional, clinical instruments. In the present study, 82 HIV+ men, who were all believed on clinical grounds to have neurobehavioral impairment. completed a traditional NP battery (TNB) and the California Computerized Assessment Package (CalCAP, a collection of computerized reaction time tests). Summary scores based on a TNB, as well as those based on the CalCAP, demonstrated significant associations with both degree of immunosuppression (CD4 count) and detectable viral load in cerebrospinal fluid, but not with detectable viral load in plasma. Established norms on the TNB and CalCAP batteries resulted in classifying 57% and 49% of the HIV+ sample as impaired, respectively. When using the TNB as the "gold standard," impairment classifications based on CalCAP summary scores exhibited a sensitivity of 68% and a specificity of 77%. Overall agreement on impairment classifications between batteries was low (kappa =.44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments.