MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
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DOI：
10.1097/00003226-199107000-00001
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发表时间：
1991-07-01
期刊：
影响因子：
2.8
通讯作者：
JESTER, JV
中科院分区：
文献类型：
--
作者：
MATHERS, WD;SHIELDS, WJ;JESTER, JV
我们使用睑板腺表达、睑板造影、泪液渗透压和Schirmer试验检查了57例有慢性睑炎症状的患者。我们还对20例无慢性睑炎的正常患者进行了meigraphy。我们发现42名睑炎患者（74%）有睑板腺脱落的证据，而20名正常患者中只有4名（20%）有任何腺体脱落。我们对眼睑炎患者的资料进行聚类分析，发现这些患者往往属于具有临床相关特征的不同群体。我们还发现泪液渗透压与腺体滴度呈正相关（+0.413），与排泄物体积负相关（-0.499）。本研究表明，睑板腺功能的客观分析可用于评估慢性睑板炎，并确定睑板炎亚群的可测量差异。这也支持睑板腺功能障碍对泪液渗透压和眼睛蒸发状态的意义。
We examined 57 patients with symptoms of chronic blepharitis using meibomian gland expression, meibography, tear osmolarity, and the Schirmer's test. We also performed meibography on 20 normal patients free of chronic blepharitis. We found that 42 blepharitis patients (74%) had evidence of meibomian gland loss, whereas only four of 20 normal patients (20%) had any gland dropout. We performed cluster analysis on the data from the patients with blepharitis and found that these patients tended to fall into distinct groups with clinically relevant characteristics. We also found that tear osmolarity correlated positively with gland dropout ( +0.413) and negatively with excreta volume ( -0.499). This study demonstrates that an objective analysis of meibomian gland function may be used to assess chronic blepharitis and define subsets of blepharitis with measurable differences. It also supports the significance of meibomian gland dysfunction on tear osmolarity and the evaporative state of the eye.