Growth of children conceived by IVF and ICSI up to 12 years of age
Growth of children conceived by IVF and ICSI up to 12 years of age
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DOI：
10.1016/j.rbmo.2009.10.006
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Sutcliffe, Alastair
中科院分区：
文献类型：
--
作者：
Basatemur, Emre;Shevlin, Mark;Sutcliffe, Alastair
最近的研究对辅助生殖治疗后出生的儿童在18岁之前的生长情况给出了相互矛盾的结果。有人认为，通过体外受精孕育的孩子可能比自然孕育的孩子更破烂，这可能是由于体外受精过程中印记基因的微妙表观遗传改变。进行了一项前瞻性匹配对照研究，以调查在英国出生的儿童在标准体外受精和卵胞浆内单精子注射（ICSI）后的生长情况，直至12岁。该研究评估了143名IVF和166名ICSI儿童，其中173名与自然受孕的对照组相匹配。主要终点是出生、5岁、7-9岁和10-12岁各时间点的身高和体重。此外，在出生时评估头围。在任何时间点，三组之间的头围、身高和体重均无显著差异。总之，这项初步研究提供了关于试管婴儿和ICSI儿童生长到12岁的可靠信息。进一步的研究必须继续调查辅助受孕儿童从青春期发育到成年早期的生长和其他结果。(C) 2009年，生殖保健有限公司。Elsevier Ltd.出版。版权所有。
Recent studies have given conflicting results regarding growth in children born following assisted reproductive treatments up to the age of 18 years. It has been suggested that children conceived via IVF may be tatter than naturally conceived children and that this may due to subtle epigenetic alteration of imprinted genes as a result of the IVF process. A prospective match-controlled study was performed to investigate the growth of children born in the UK following standard IVF and intracytoplasmic sperm injection (ICSI) up to the age of 12 years. The study assessed 143 IVF and 166 ICSI children with 173 matched naturally conceived controls. Primary end-points were height and weight at various time points: birth, 5 years, 7-9 years and 10-12 years. In addition, head circumference was assessed at birth. No significant differences were observed regarding head circumference, height and weight between the three groups at any of the time points. In conclusion, this preliminary study provides reassuring information regarding the growth of IVF and ICSI children up to 12 years. Further studies must continue to investigate the growth and other outcomes in assisted-conception children as they develop through puberty into early adulthood. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.