Early-life photoperiod influences depression-like behavior, prepulse inhibition of the acoustic startle response, and hippocampal astrogenesis in mice
Early-life photoperiod influences depression-like behavior, prepulse inhibition of the acoustic startle response, and hippocampal astrogenesis in mice
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生命早期的光周期影响小鼠的抑郁样行为、声惊吓反应的前脉冲抑制和海马星形体发生
DOI：
10.1016/j.neuroscience.2018.01.038
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发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Yasuo S
中科院分区：
文献类型：
--
作者：
Takai Y;Kawai M;Ogo T;Ichinose T;Furuya S;Takaki N;Tone Y;Udo H;Furuse M;Yasuo S
生命早期阶段的环境因素影响成年期的行为和生理表型。我们使用C57 BL/6 J小鼠研究了发育过程中光周期对青春期/成年期神经发生和情感行为的影响。小鼠出生并在长日条件（LD）或短日条件（SD）下饲养直至断奶，随后是12 L12 D周期直至成年。在强迫游泳试验中，SD组小鼠的第一次不动潜伏期比LD组短。在SD下出生的小鼠也表现出显著较低的前脉冲抑制，这是精神分裂症的特征。然而，仅在产前期间暴露于SD和LD的小鼠在前脉冲抑制方面没有表现出差异。4周龄时，SD组小鼠海马齿状回（DG）内5-溴-2 ′-脱氧尿苷（BrdU）阳性细胞数少于LD组。免疫双染色显示，与LD下出生的小鼠相比，SD下出生的小鼠显示较少的BrdU/胶质细胞酸性蛋白（GFAP，星形胶质细胞标记物）细胞。此外，糖皮质激素受体在DG中的表达更高，在SD下出生的小鼠，和光周期依赖性的变化，在DG中的BrdU阳性细胞的数量被取消的管理RU 486，糖皮质激素受体拮抗剂。这些结果表明，在生命早期的光周期通过下丘脑-垂体-肾上腺轴改变海马的星形发生，并可能与成年期的情感行为。
Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditions (LDs) or short-day conditions (SDs), followed by a 12L12D cycle until adulthood. Adult mice born under SD showed a shorter latency to first immobility in the forced swim test when compared with the mice born under LD. The mice born under SD also exhibited significantly lower prepulse inhibition, which is a characteristic of schizophrenia. However, the mice exposed to SD and LD during the prenatal period only did not show differences in prepulse inhibition. At 4 weeks of age, there were less 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus (DG) of the hippocampus of mice born under SD when compared with mice born under LD. Double immunostaining showed that the mice born under SD showed less BrdU/glial fibrillary acidic protein (GFAP, an astrocyte marker) cells when compared with mice born under LD. Furthermore, expression of the glucocorticoid receptor in the DG was higher in mice born under SD, and the photoperiod-dependent changes in the number of BrdU-positive cells in the DG were abolished by administration of RU486, a glucocorticoid receptor antagonist. These results suggest that the photoperiod in early life alters astrogenesis in the hippocampus via the hypothalamic–pituitary-adrenal axis and may relate to affective behaviors in adulthood.