Medically attended pediatric influenza during the resurgence of the Victoria lineage of influenza B virus
Medically attended pediatric influenza during the resurgence of the Victoria lineage of influenza B virus
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DOI：
10.1016/j.ijid.2005.10.008
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发表时间：
2007-01-01
影响因子：
8.4
通讯作者：
Munoz, Flor M.
中科院分区：
文献类型：
--
作者：
Hite, Ladonna K.;Glezen, W. Paul;Munoz, Flor M.
目的：在2002-2003年流感季节，一种新的流感病毒变种B与甲型流感病毒共同传播。本研究探讨了甲型和B型流感病毒感染儿童与其他急性呼吸道疾病儿童的特征和结局。方法：对实验室确诊的流感感染儿童和流感阴性急性呼吸道疾病儿童进行了回顾性病历审查，并促使其住院。结果：流感儿童通常以前健康，并出现上呼吸道症状，白色流感阴性患者通常有基础疾病，和下呼吸道疾病。患B型流感的儿童比患A型流感的儿童年龄更大，更有可能上学，并且更频繁地出现肌炎。三分之一的甲型流感儿童和42%的B流感儿童需要住院治疗。一岁以下婴儿的住院率最高。没有健康的儿童，只有15%的慢性疾病患者接种过流感疫苗。结论：流感患儿既往健康状况良好。总体而言，三分之一的流感儿童需要住院治疗。甲型流感和B型流感在临床上难以区分，但B型流感患者年龄较大且肌炎发生率较高。健康儿童和高危儿童的流感疫苗覆盖率为2。(c)2006年国际传染病学会。出版社：Elsevier Ltd. rights reserved.
Objectives: During the 2002-2003 season, a new variant of influenza B co-circulated with influenza A viruses. This study examines the characteristics and outcomes of children with influenza A and B virus infection vs. other acute respiratory illnesses.Methods: A retrospective chart review was performed on children with laboratory-confirmed influenza infection, and influenza negative acute respiratory illnesses that prompted a hospital visit.Results: Children with influenza were more often previously healthy and presenting with upper respiratory symptoms, white influenza negative patients typically had underlying medical conditions, and lower respiratory tract disease. Children with influenza B were older, were more likely to be in school, and presented with myositis more frequently than those with influenza A. A third of children with influenza A, and 42% with influenza B required hospitalization. The highest hospitalization rates were in infants under one year. No healthy children, and only 15% of those with chronic medical problems, had received influenza vaccine. Vaccine efficacy was estimated to be 82.6%.Conclusions: Most children with influenza were previously healthy. Overall, a third of children with influenza required hospitalization. Influenza A and B were clinically indistinguishable, except for older age and higher incidence of myositis in patients with influenza B. Influenza vaccine coverage in both healthy and high-risk children was tow. (c) 2006 International Society for Infectious Diseases. Published by Elsevier Ltd. All. rights reserved.