Learning and memory in the vestibulo-ocular reflex.
Learning and memory in the vestibulo-ocular reflex.
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DOI：
10.1146/annurev.ne.18.030195.002205
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发表时间：
1995
影响因子：
13.9
通讯作者：
S. Lac;Jennifer;L. Raymond;T. J. Sejnowskiz;S. Lisberger
中科院分区：
文献类型：
--
作者：
S. Lac;Jennifer;L. Raymond;T. J. Sejnowskiz;S. Lisberger
研究完整动物的学习和记忆的神经基础，就其本质而言，必须从“自上而下”开始，选择一种可以通过学习来改变的行为，揭示神经元活动如何引起这种行为，然后在清醒的行为动物中调查与学习相关的神经信号的变化。这些研究还必须认识到，动物行为中表达的学习和记忆既反映了调节行为的神经网络的性质，也反映了细胞或突触运作中潜在变化的性质。在过去的10年里，清醒的猴子的前庭眼反射（VOR）中关于学习和记忆的信息激增。与此同时，对细胞可塑性机制的理解也取得了前所未有的进展，如海马的长时程增强（LTP）和小脑的长时程抑制（LTD）。理解学习和记忆的先决条件是将细胞可塑性的特定机制提升为学习的细胞机制，方法是在神经系统的背景下建立它们的功能，该神经系统介导特定行为中的学习和记忆。我们的评论综合了
Studies of the neural basis of learning and memory in intact animals must, by their nature, start "from the top" by choosing a behavior that can be modified through learning, revealing how iaeuronal activity gives rise to that behavior, and then investigating, in the awake, behaving animal, changes in neural signaling that are associated with learning. Such studies also must recognize that the learning and memory expressed in the behavior of an animal will reflect both the properties of the neural network that mediates the behavior and the nature of the underlying changes in the operation of cells or synapses. In the past 10 years, there has been an explosion of information about learning and memory in the vestibulo-ocular reflex (VOR) of the awake, behaving monkey. At the same time, there have been unprecedented advances in understanding mechanisms of cellular plasticity such as long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. A prerequisite for understanding learning and memory is to elevate specific mechanisms of cellular plasticity into cellular mechanisms of learning by establishing their function in the context of a neural system that mediates learning and memory in a particular behavior. Our review synthesizes the