CHIRAL 2-CYANO ESTERS AS SYNTHETIC INTERMEDIATES IN THE SYNTHESIS OF R-ALPHA-METHYLVALINE AND S-ALPHA-METHYLVALINE
CHIRAL 2-CYANO ESTERS AS SYNTHETIC INTERMEDIATES IN THE SYNTHESIS OF R-ALPHA-METHYLVALINE AND S-ALPHA-METHYLVALINE
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DOI：
10.1016/0040-4020(95)00260-f
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发表时间：
1995-05-15
期刊：
影响因子：
2.1
通讯作者：
LAPENA, Y
中科院分区：
文献类型：
--
作者：
CATIVIELA, C;DIAZDEVILLEGAS, MD;LAPENA, Y
以（2 RS）（1 S，2 R，4 R）-10-二环己基氨磺酰基异丙基2-氰基-3-甲基丁酸酯为起始原料，立体选择性合成了R和S α-甲基缬氨酸。
A divergent stereoselective synthesis of R and S alpha-methylvaline from (2RS) (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3-methylbutanoate has been developed.