Differences in quantitative EEG between frontotemporal dementia and Alzheimer's disease as revealed by LORETA
Differences in quantitative EEG between frontotemporal dementia and Alzheimer's disease as revealed by LORETA
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DOI：
10.1016/j.clinph.2011.02.011
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发表时间：
2011-09-01
影响因子：
4.7
通讯作者：
Kinoshita, T.
中科院分区：
文献类型：
--
作者：
Nishida, K.;Yoshimura, M.;Kinoshita, T.
目的：探讨额颞叶痴呆（FTD）的电生理特征及其与阿尔茨海默病（AD）的区别。方法：我们分析了轻度FTD （n = 19，平均年龄= 68.11 +/- 7.77）和AD （n = 19，平均年龄= 69.42 +/- 9.57）患者和正常对照（NC）受试者（n = 22，平均年龄= 66.13 +/- 6.02）患者的全脑电场功率（GFP），并使用sLORETA（标准化低分辨率电磁断层扫描）进行脑电图神经成像分析。结果：在GFP分析中，delta （1.5 ~ 6.0 Hz）、alpha1 （8.5 ~ 10.0 Hz）和beta1 （12.5 ~ 18.0 Hz）波段存在显著的群体效应。在sLORETA分析中，观察到眶额叶和颞叶的α 1带（NC > FTD）、额叶等广泛区域的δ带（AD > NC）和顶叶和感觉运动区β 1带（FTD > AD）活性的差异。结论：在病理活动方面，FTD组和AD组的脑区模式和脑电图频带存在差异。意义：早期FTD和AD患者在不同频带的皮层振荡活动定位模式不同。(C) 2011年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To determine the electrophysiological characteristics of frontotemporal dementia (FTD) and the distinction with Alzheimer's disease (AD).Methods: We performed analyses of global field power (GFP) which is a measure of whole brain electric field strength, and EEG neuroimaging analyses with sLORETA (standardized low resolution electromagnetic tomography), in the mild stages of FTD (n = 19; mean age = 68.11 +/- 7.77) and AD (n = 19; mean age = 69.42 +/- 9.57) patients, and normal control (NC) subjects (n = 22; mean age = 66.13 +/- 6.02).Results: In the GFP analysis, significant group effects were observed in the delta (1.5-6.0 Hz), alpha1 (8.5-10.0 Hz), and beta1 (12.5-18.0 Hz) bands. In sLORETA analysis, differences in activity were observed in the alpha1 band (NC > FTD) in the orbital frontal and temporal lobe, in the delta band (AD > NC) in widespread areas including the frontal lobe, and in the beta1 band (FTD > AD) in the parietal lobe and sensorimotor area.Conclusions: Differential patterns of brain regions and EEG frequency bands were observed between the FTD and AD groups in terms of pathological activity.Significance: FTD and AD patients in the early stages displayed different patterns in the cortical localization of oscillatory activity across different frequency bands. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.