Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells
Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells
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DOI：
10.1021/jo051352x
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发表时间：
2005-10-28
影响因子：
3.6
通讯作者：
Oshima, Y
中科院分区：
文献类型：
--
作者：
Kikuchi, H;Saito, Y;Oshima, Y
我们已经探索了由细胞黏菌产生的次级代谢产物的多样性，以研究这种细胞黏菌作为新药开发资源的可能用途。从Dictyosteremebrefeldianum和D. giganteum.通过EIMS、H-1和C-13 NMR等波谱方法确定了化合物1的结构。进行1的全合成以确认结构并获得足够的样品用于进行生物学评价。有趣的是，化合物1抑制1321 N1人星形细胞瘤细胞的细胞增殖。
We have explored the diversity of secondary metabolites produced by cellular slime molds to examine the possible use of such cellular slime molds as a resource for novel drug development. A new aromatic amide, brefelamide (1), was isolated from methanol extracts of the fruiting bodies of Dictyostelium brefeldianum and D. giganteum. The structure of 1 was determined by spectral means including EIMS and H-1 and C-13 NMR. The total synthesis of 1 was carried out to confirm the structure and obtain sufficient samples for performing biological evaluation. Interestingly, compound 1 inhibited the cellular proliferation of 1321N1 human astrocytoma cells.