Uric Acid as a Potential Cue to Screen for Iron Overload
Uric Acid as a Potential Cue to Screen for Iron Overload
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DOI：
10.3122/jabfm.2011.04.110015
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发表时间：
2011-07
期刊：
影响因子：
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通讯作者：
A. Mainous;Michele E. Knoll;C. J. Everett;Eric M. Matheson;M. Hulihan;Althea M. Grant
中科院分区：
文献类型：
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作者：
A. Mainous;Michele E. Knoll;C. J. Everett;Eric M. Matheson;M. Hulihan;Althea M. Grant
背景：提示血色素沉着症和铁超载的靶向筛查可能是值得的。这项研究的目的是检查尿酸作为铁超载存在的潜在指标。方法：对1999 ~ 2002年全国健康与营养调查中年龄在20岁及以上的成年人进行分析。我们计算了控制年龄、性别、种族/民族、肝脏或肾脏状况和饮酒的逻辑回归，以观察尿酸和铁蛋白组合与肝酶升高和蛋白尿结果之间的关系。结果：在未经调整的分析中，20.7%的高尿酸患者有高铁蛋白水平，而8.8%的低尿酸患者有高铁蛋白水平（P < 0.001）。尿酸和铁蛋白水平均升高的个体，其肝酶水平明显高于尿酸或铁蛋白水平均升高的个体。以低尿酸和低铁蛋白为参照类别，高尿酸和高铁蛋白的个体同时发生蛋白尿的可能性显著增加（优势比2.66;95% CI 1.82-3.91）。结论：尿酸水平升高与铁蛋白水平升高相关，可能是铁超载和血色素沉着症的危险分层变量。
Background: It is suggested that targeted screening for hemochromatosis and iron overload may be worthwhile. The aim of this study was to examine uric acid as a potential indicator of the presence of iron overload. Methods: We analyzed adults aged 20 and older in the National Health and Nutrition Examination Survey 1999 to 2002. We computed logistic regressions controlling for age, sex, race/ethnicity, liver or kidney condition, and alcohol use to see the relationship between combinations of uric acid and ferritin with the outcomes of elevated liver enzymes and proteinuria. Results: In unadjusted analyses, 20.7% of individuals with high uric acid had high ferritin levels versus 8.8% of individuals with low uric acid levels (P < .001). Individuals with both elevated uric acid and elevated ferritin levels had significantly higher liver enzymes than individuals with either elevated uric acid or ferritin. With low uric acid and low ferritin as the reference category, individuals with high uric acid and high ferritin were significantly more likely to also have proteinuria (odds ratio, 2.66; 95% CI, 1.82–3.91). Conclusions: Elevated levels of uric acid is associated with elevated ferritin levels and may serve as a risk stratification variable for presence of iron overload and hemochromatosis.