FORMATION AND METABOLISM OF PUNGENT PRINCIPLE OF CAPSICUM FRUITS .19. CAPSAICIN, A PUNGENT PRINCIPLE OF HOT RED-PEPPER, EVOKES CATECHOLAMINE SECRETION FROM THE ADRENAL-MEDULLA OF ANESTHETIZED RATS
FORMATION AND METABOLISM OF PUNGENT PRINCIPLE OF CAPSICUM FRUITS .19. CAPSAICIN, A PUNGENT PRINCIPLE OF HOT RED-PEPPER, EVOKES CATECHOLAMINE SECRETION FROM THE ADRENAL-MEDULLA OF ANESTHETIZED RATS
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DOI：
10.1016/0006-291x(87)90479-7
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发表时间：
1987-01-15
影响因子：
3.1
通讯作者：
IWAI, K
中科院分区：
文献类型：
--
作者：
WATANABE, T;KAWADA, T;IWAI, K
利用儿茶酚胺(CA)分泌到肾上腺静脉的直接监测系统，我们证明了辣椒素(CAP)能引起戊巴比妥钠麻醉大鼠肾上腺髓质CA的分泌。静脉注射CAP(200微克/公斤)可显著增加大鼠肾上腺素(E)的分泌。在输液后没有可检测到的滞后。CAP引起的去甲肾上腺素(NE)分泌较E弱。CAP诱导的E分泌呈剂量-剂量依赖性。CAP对E释放的刺激作用在20ug/kg时几乎检测不到，100ug/kg时一半最大，600ug/kg时最大。灌胃CAP(200微克/千克)时，E/NE重量比(47.6)显著高于乙酰胆碱(12.5微克/千克)(13.0)。这些结果表明，CAP可引起大鼠肾上腺髓质CA分泌。
Using a direct monitoring system for catecholamine (CA) secretion into the adrenal vein, we have demonstrated that capsaicin (CAP) evokes CA secretion from the adrenal medulla of pentobarbital-anesthetized rats. A significant increase in epinephrine (E) secretion was seen in rats infused with CAP (200 .mu.g/kg, i.v.) without a detectable lag after the infusion. Norepinephrine (NE) secretion evoked by CAP was fairly weak compared with E secretion. The secretion of E evoked by CAP was dose-amount dependent. The stimulation of E release by CAP was barely detectable at 20 .mu.g/kg, half-maximal at 100 .mu.g/kg, and maximal at 600 .mu.g/kg. When CAP (200 .mu.g/kg) was infused into rats, the weight-ratio of E to NE was significantly higher (47.6) than when acetylcholine (12.5 .mu.g/kg) was infused (13.0). These results indicate that CAP can evoke CA secretion from the adrenal medulla of rats.