When host defense goes awry: Modeling sepsis-induced immunosuppression.
When host defense goes awry: Modeling sepsis-induced immunosuppression.
复制标题
DOI：
10.1016/j.ddmod.2011.09.001
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
脓毒症与最初的高炎症状态有关；然而，针对炎症反应的治疗试验产生了令人失望的结果。现在认识到，脓毒症患者往往经历一段时间的相对免疫抑制，使他们容易继发感染。对这一现象的兴趣导致了动物模型的发展，以研究败血症的免疫功能障碍。在这篇综述中，我们分析了现有的脓毒症诱导的免疫抑制模型。
Sepsis is associated with an initial hyperinflammatory state; however, therapeutic trials targeting the inflammatory response have yielded disappointing results. It is now appreciated that septic patients often undergo a period of relative immunosuppression, rendering them susceptible to secondary infections. Interest in this phenomenon has led to the development of animal models to study the immune dysfunction of sepsis. In this review, we analyze the available models of sepsis-induced immunosuppression.