MORPHOMETRIC ANALYSIS OF DEVELOPING RAT CEREBRAL-CORTEX FOLLOWING ACUTE PRENATAL ETHANOL EXPOSURE
MORPHOMETRIC ANALYSIS OF DEVELOPING RAT CEREBRAL-CORTEX FOLLOWING ACUTE PRENATAL ETHANOL EXPOSURE
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DOI：
10.1016/0014-4886(89)90161-1
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发表时间：
1989-12-01
影响因子：
5.3
通讯作者：
NORTON, S
中科院分区：
文献类型：
--
作者：
KOTKOSKIE, LA;NORTON, S
胎鼠大脑皮质的形态学改变定量的形态学分析后，急性乙醇暴露在Geodynamic第14天，大脑皮质发育的关键时期。妊娠大鼠在第14天接受总剂量为9 g/kg的乙醇插管。母亲的血液乙醇水平范围从51到202毫克%的乙醇暴露期间。在吉西他滨第15天，乙醇末次给药后24 h检查胎仔脑。与乙醇暴露相关的急性形态学变化包括室管膜下区核增大、皮质肿胀和受累皮质上软脑膜血管扩张。在一些胎仔中，皮质肿胀伴随着脑室区细胞的胞质泡突出到侧脑室中。它的结论是，母亲的乙醇暴露在大脑发育的关键时期产生可测量的形态学变化，在胎鼠大脑皮层乙醇暴露后24小时内。
Morphologic alterations of fetal rat cerebral cortex were quantified by morphometric analysis following acute ethanol exposure on Gestational Day 14, a critical period of development of cerebral cortex. Pregnant rats were intubated with a total dose of 9 g/kg of ethanol on Gestational Day 14. Maternal blood ethanol levels ranged from 51 to 202 mg% during the period of ethanol exposure. Fetal brains were examined on Gestational Day 15, 24 h after the last dose of ethanol. The acute morphologic changes associated with ethanol exposure include enlargement of subventricular zone nuclei, cortical swelling, and dilation of pial blood vessels over the affected cortex. In some fetuses, cortical swelling was accompanied by the protrusion into the lateral ventricles of cytoplasmic blebs of ventricular zone cells. It is concluded that maternal ethanol exposure during a critical period of brain development produces measurable morphologic changes in fetal rat cerebral cortex within 24 h after ethanol exposure.