Effects of aging and sediment composition on hexachlorobenzene desorption resistance compared to oral bioavailability in rats
Effects of aging and sediment composition on hexachlorobenzene desorption resistance compared to oral bioavailability in rats
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DOI：
10.1016/j.chemosphere.2008.02.025
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发表时间：
2008-06-01
期刊：
影响因子：
8.8
通讯作者：
Bartels, Michael J.
中科院分区：
文献类型：
--
作者：
Chai, Yunzhou;Davis, John W.;Bartels, Michael J.
研究了黑碳、粘土类型和老化（1 - 1.5年）对加标人工沉积物中六氯苯（HCB）的解吸和生物有效性的影响。Tenax（一种超强吸附剂）介导的解吸被用来检查这些参数对六氯苯的物理化学可用性的影响。Tenax介导的解吸六氯苯从四个年龄的人工沉积物表现出双相动力学。快速解吸组分的范围从64.8%到22.3%，显示出4.0 - 18.9%，与新鲜加标的沉积物相比，减少。对快速解吸级分的统计分析表明，所有三种处理效果（即，蒙脱石粘土、炭黑含量和老化）显著。具有较高黑碳含量的两种沉积物表现出大得多的老化效应（即，快速脱附部分的更大减少）比不添加黑碳的其它两种沉积物。对于新加标的沉积物和老化的沉积物，缓慢解吸部分）与先前报告的大鼠粪便中六氯苯的消除情况有相当好的相关性，这是对沉积物中结合六氯苯的非生物利用部分的一种衡量。在快速解吸部分和先前报告的六氯苯在大鼠体内（尸体+皮肤）的累积之间也观察到类似的相关性。这些观察结果表明，根据沉积物中六氯苯的解吸作用确定的物理化学可利用性，可以合理预测大鼠口服沉积物中的六氯苯的生物利用度。这些结果表明，蒙脱石粘土，黑碳和老化降低物理化学有效性和最终的生物利用度的沉积物结合六氯苯。(C)2008爱思唯尔有限公司保留所有权利。
Studies were conducted to assess the effects of black carbon, clay type and aging (1-1.5 yr) on desorption and bioavailability of hexachlorobenzene (HCB) in spiked artificial sediments. Tenax (a super sorbent)-mediated desorption was used to examine the effects of these parameters on the physicochemical availability of HCB. The Tenax-mediated desorption of HCB from the four aged artificial sediments exhibited biphasic kinetics. The fast desorbing fractions ranged from 64.8% to 22.3%, showing reductions of 4.0-18.9% compared with freshly-spiked sediments. Statistical analysis on the fast desorbing fractions showed that all three treatment effects (i.e., montmorillonite clay, black carbon content, and aging) were significant. Two sediments with higher black carbon content exhibited much greater aging effects (i.e., greater reduction in fast desorbing fraction) than the other two sediments without the addition of black carbon. For both freshly-spiked and aged sediments, the desorption resistant sediment-bound HCB (i.e., slow desorbing fraction) correlated reasonably well to previously reported rat fecal elimination of HCB, which is a measure of the non-bioavailable fraction of sediment-bound HCB. A similar correlation was also observed between fast desorbing fraction and previously reported accumulation of HCB in the rat body (carcass + skin). These observations suggest that physicochemical availability, as defined by the desorption of HCB from sediments, provides a reasonable prediction of the oral bioavailability of sediment-bound HCB to rats. These results showed that montmorillonite clay, black carbon and aging reduced physicochemical availability and ultimately bioavailability of sediment-bound HCB. (C) 2008 Elsevier Ltd. All rights reserved.