Estimated radiation risks potentially associated with full-body CT screening
Estimated radiation risks potentially associated with full-body CT screening
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DOI：
10.1148/radiol.2323031095
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发表时间：
2004-09-01
期刊：
影响因子：
19.7
通讯作者：
Elliston, CD
中科院分区：
文献类型：
--
作者：
Brenner, DJ;Elliston, CD
目得：估计辐射相关的癌症死亡率风险与单次或多次全身计算机断层扫描（CT）检查，通过使用标准的辐射风险estimations.MATERIALS和METHODS：估计剂量的肺或胃从一个单一的全身CT检查是14-21毫戈瑞，这对应于一个剂量区域，有直接证据表明，增加癌症死亡率在原子弹爆炸幸存者。重复检查的总剂量相应较高。作者使用从原子弹相关癌症死亡率数据中得出的美国人群的估计癌症风险，以及从全身CT检查中计算的器官剂量，来估计与单次和多次全身CT检查相关的辐射风险。结果：一个45岁的成年人进行一次全身CT检查，估计一生中归因于癌症的死亡风险约为0.08%，其中95%的可信度极限在任一方向上是3.2的因子。一个45岁的成年人谁计划每年进行全身CT检查到75岁（30次检查）将累积一个整体的估计终身归因于癌症死亡率的风险约为1.9%，与95%的可信度限制是一个因素2在任一方向。结论：作者提供了估计终身癌症死亡率风险从单次和每年的全身CT检查。需要这些风险估计来从个人和公共卫生的角度评估全身CT检查的效用。(C)RSNA，2004年。
PURPOSE: To estimate the radiation-related cancer mortality risks associated with single or repeated full-body computed tomographic (CT) examinations by using standard radiation risk estimation methods.MATERIALS AND METHODS: The estimated dose to the lung or stomach from a single full-body CT examination is 14-21 mGy, which corresponds to a dose region for which there is direct evidence of increased cancer mortality in atomic bomb survivors. Total doses for repeated examinations are correspondingly higher. The authors used estimated cancer risks in a U.S. population derived from atomic bomb-associated cancer mortality data, together with calculated organ doses from a full-body CT examination, to estimate the radiation risks associated with single and multiple full-body CT examinations.RESULTS: A single full-body CT examination in a 45-year-old adult would result in an estimated lifetime attributable cancer mortality risk of around 0.08%, with the 95% credibility limits being a factor of 3.2 in either direction. A 45-year-old adult who plans to undergo annual full-body CT examinations up to age 75 (30 examinations) would accrue an overall estimated lifetime attributable risk of cancer mortality of about 1.9%, with the 95% credibility limits being a factor of 2 in either direction.CONCLUSION: The authors provide estimates of lifetime cancer mortality risks from both single and annual full-body CT examinations. These risk estimates are needed to assess the utility of full-body CT examinations from both an individual and a public health perspective. (C) RSNA, 2004.