Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome
Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome
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DOI：
10.2334/josnusd.18-0431
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发表时间：
2020-03-01
影响因子：
1.9
通讯作者：
Imamura, Yoshiki
中科院分区：
文献类型：
--
作者：
Kohashi, Ryutaro;Shinozaki, Takahiro;Imamura, Yoshiki
灼口综合征（BMS）被归类为特发性口腔面部疼痛。虽然中枢和周围神经病变机制被认为涉及，病因仍有待充分阐明。本研究检查了颞叶脑对持续热刺激的反应，以研究BMS患者的疼痛调节系统。热刺激顺序包括基线（32℃，40 s）→暖（40℃，32 s）→基线（32℃，40 s）→热（49℃，32 s），使用Peltier热模器重复4次。这些温暖和热的刺激分别应用于右手掌和右下唇。功能磁共振成像数据采用块设计记录回波平面图像。在BMS患者中，与对照组相比，应用于手掌的纯热刺激（49℃vs. 40℃）诱导的脑活动比唇刺激诱导的更明显。比较刺激前16秒和后16秒的脑活动，发现BMS患者在刺激嘴唇时具有明显的时间依赖性促进。这些发现表明，BMS患者的疼痛调节系统失调，BMS患者的大脑对来自三叉神经系统的疼痛信息高度敏感。
Burning mouth syndrome (BMS) is classified into idiopathic orofacial pain conditions. Although central and peripheral neuropathic mechanisms are believed to be involved, the etiology remains to be fully elucidated. The present study examined temporal brain responses to an ongoing hot stimulus to investigate the pain modulating system in patients with BMS. The thermal stimulation sequence comprised baseline (32 degrees C, 40 s) to warm (40 degrees C, 32 s) to baseline (32 degrees C, 40 s) to hot (49 degrees C, 32 s), which was repeated four times using a Peltier thermode. These warm and hot stimuli were applied on the right palm and right lower lip in two separate sessions. Functional magnetic resonance imaging data were acquired by recording echo-planar images with a block design. Brain activity induced by purely hot stimulation (49 degrees C vs. 40 degrees C) applied to the palm was more pronounced than that induced by lip stimulation and in patients with BMS compared with controls. Comparison of brain activity between the first 16 s and second 16 s of the stimulus revealed pronounced time-dependent facilitation in patients with BMS during lip stimulation. These findings indicate that the pain modulating system in patients with BMS is dysregulated and that the brain in BMS is highly sensitized to pain information originating from the trigeminal system.