THE RELATION BETWEEN CONSTITUTIONAL SKIN COLOR AND PHOTOSENSITIVITY ESTIMATED FROM UV-INDUCED ERYTHEMA AND PIGMENTATION DOSE-RESPONSE CURVES
THE RELATION BETWEEN CONSTITUTIONAL SKIN COLOR AND PHOTOSENSITIVITY ESTIMATED FROM UV-INDUCED ERYTHEMA AND PIGMENTATION DOSE-RESPONSE CURVES
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DOI：
10.1111/1523-1747.ep12874671
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发表时间：
1990-06-01
影响因子：
6.5
通讯作者：
CARIO, I
中科院分区：
文献类型：
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作者：
WESTERHOF, W;ESTEVEZUSCANGA, O;CARIO, I
在54名健康志愿者中，我们评估了对紫外线（UV）光敏感性的预测因素，包括Fitzpatrick的阳光反应性皮肤类型和体质皮肤颜色，并将这些因素相互比较，并与皮肤对UV照射的反应进行比较，如通过最小红斑剂量（MED），最小黑素生成剂量（MMD）以及UV诱导的红斑和色素沉着的剂量-反应曲线实验确定的。在这些研究中，氙弧太阳模拟器被用作紫外线照射源，并采用与计算机接口的chromoprotein来客观测量紫外线诱导的红斑和色素沉着。皮肤类型并不完全对应于体质皮肤颜色，如在UV照射之前通过比色计测量的。在每种皮肤类型中，MED和MMD值的范围很大，剂量-反应曲线的形状变化很大。体质肤色也不是测量MED和MMD值的良好预测因子，但似乎与红斑和色素沉着的剂量反应曲线的陡峭度相关。从这些研究中，我们提出，客观测量的体质皮肤颜色是一个更好的预测皮肤的紫外线反应比皮肤类型和红斑的剂量-反应曲线的陡度是一个更好的措施，皮肤的紫外线照射的反应比MED测量。
In 54 healthy volunteer we assessed predictors of sensitivity to ultraviolet (UV) light, including Fitzpatrick''s sun reactive skin types and constitutional skin color, and compared these with one another and with responses of the skin to UV irradiation, as determined experimentally by a minimal erythema dose (MED), a minimal melanogenic dose (MMD), and dose-response curves for UV-induced erythema and pigmentation. For these studies, a xenon arc solar simulator was used as the source of UV irradiation, and a chromameter interfaced with a computer for objective measurement of UV-induced erythema and pigmentation was employed. The skin type did not correspond well to the constitutional skin color, as measured by a chromameter prior to UV irradiation. Within each skin type, there were large range of MED and MMD values and great variability in the shapes of the dose-response curves. Constitutional skin color was also not a good predictor of the measure MED and MMD values but did appear to correlate with the steepness of the dose-response curves for erythema and for pigmentation. From these studies, we propose that objectively measured constitutional skin color is a better predictor of UV responses of the skin than skin type and that steepness of dose-response curves for erythema is a better measure of the response of the skin to UV irradiation than is a MED measurement.