ARC synergizes with ABT-737 to induce apoptosis in human cancer cells.
ARC synergizes with ABT-737 to induce apoptosis in human cancer cells.
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DOI：
10.1158/1535-7163.mct-09-0919
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发表时间：
2010-06
影响因子：
5.7
通讯作者：
Gartel AL
中科院分区：
文献类型：
--
作者：
Bhat UG;Pandit B;Gartel AL
Previously, we reported that the nucleoside analog/transcriptional inhibitor ARC was able to induce p53-independent apoptosis in multiple cancer cell lines of different origin. This occurred at least in part by the suppression of short-lived, pro-survival member of the Bcl-2 family, Mcl-1. In contrast, we show here that treatment of human cancer cells with the pan-Bcl-2 inhibitor ABT-737 alone led to up-regulation of Mcl-1 protein expression. Combination of sub-apoptotic concentrations of ABT-737 and ARC induced mitochondrial injury and potent caspase-3/caspase-9-dependent apoptosis in wide variety of human cancer cell lines. These data suggest that ABT-737/ARC combination that simultaneously targets Bcl-2 and Mcl-1 may be efficient against human cancer.
