N3-benzyluridine exerts hypnotic activity in mice.
N3-benzyluridine exerts hypnotic activity in mice.
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N3-Benzyluridine 对小鼠具有催眠活性。
DOI：
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发表时间：
1985
影响因子：
1.7
通讯作者：
I. Ho
中科院分区：
文献类型：
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作者：
I. Yamamoto;T. Kimura;Y. Tateoka;K. Watanabe;I. Ho
n3 -苄基尿嘧啶(I)是尿嘧啶（II）或尿嘧啶（III）的衍生物，对小鼠有催眠作用。I的催眠作用是通过脑室注射来实现的。剂量为1.5 ~ 4.0 μmol/只，呈剂量依赖性。此外，我显著延长了戊巴比妥诱导的小鼠睡眠。在相同剂量下，II和III没有催眠或延长睡眠的效果。正如Komoda等人所报道的，这些结果表明III可能是一种促进睡眠的物质。
N3-Benzyluridine (I), a derivative of uracil (II) or uridine (III), has hypnotic effect on mice. The hypnotic effect of I was effected by intracerebroventricular injection. The response was dose-dependent with doses of 1.5-4.0 μmol/mouse. Further, I significantly prolonged pentobarbital-induced sleep in mice. In the same doses, II and III have no hypnotic or sleep-prolonging effects. These results suggest that III may be a sleep-promoting substance basically, as reported by Komoda et al.