No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti.
No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti.
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DOI：
10.3201/eid2411.180738
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发表时间：
2018-11
影响因子：
11.8
通讯作者：
Kano S
中科院分区：
文献类型：
--
作者：
Vincent JP;Komaki-Yasuda K;Existe AV;Boncy J;Kano S
我们从海地疟疾高传播地区获得了78份人类血液样本，在恶性疟原虫氯喹耐药转运蛋白和Kelch 13基因中没有发现耐药相关突变。我们建议继续将氯喹作为海地治疗疟疾的一线药物。基于青蒿素的疗法可用作替代疗法。
We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti. Artemisinin-based therapy can be used as alternative therapy.