Pluripotent stem cell studies elucidate the underlying mechanisms of early embryonic development.
Pluripotent stem cell studies elucidate the underlying mechanisms of early embryonic development.
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多能干细胞研究阐明早期胚胎发育的潜在机制
DOI：
10.3390/genes2020298
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发表时间：
2011-03-24
期刊：
影响因子：
3.5
通讯作者：
Jing N
中科院分区：
文献类型：
--
作者：
Li L;Jing N
早期胚胎发育是一个多步骤的过程，受到各种信号通路的强烈调控。由于胚胎的复杂性和胚层之间的相互作用，很难完全理解这些信号如何调节胚胎模式。最近，来自不同发育阶段的多能干细胞系为研究调控细胞命运决定的分子机制提供了体外系统。本文综述了BMP、FGF、Nodal和Wnt信号通路在脊椎动物胚胎发生中的重要作用。然后，我们强调了最近的多能干细胞研究，揭示了BMP，FGF和Nodal通路在神经分化过程中的阶段特异性作用。这些发现增强了我们对特定信号通路对胚胎模式的逐步调节的理解，并为早期胚胎发育的机制提供了新的见解。
Early embryonic development is a multi-step process that is intensively regulated by various signaling pathways. Because of the complexity of the embryo and the interactions between the germ layers, it is very difficult to fully understand how these signals regulate embryo patterning. Recently, pluripotent stem cell lines derived from different developmental stages have provided an in vitro system for investigating molecular mechanisms regulating cell fate decisions. In this review, we summarize the major functions of the BMP, FGF, Nodal and Wnt signaling pathways, which have well-established roles in vertebrate embryogenesis. Then, we highlight recent studies in pluripotent stem cells that have revealed the stage-specific roles of BMP,FGF and Nodal pathways during neural differentiation. These findings enhance our understanding of the stepwise regulation of embryo patterning by particular signaling pathways and provide new insight into the mechanisms underlying early embryonic development.
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DOI：
10.1073/pnas.95.9.5082
发表时间：
1998-04-28
影响因子：
11.1
作者：
Arman, E;Haffner-Krausz, R;Lonai, P
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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