Optical Screening of Diabetes Mellitus using Non-invasive Fourier-transform Infrared Spectroscopy Technique for Human Lip.
Optical Screening of Diabetes Mellitus using Non-invasive Fourier-transform Infrared Spectroscopy Technique for Human Lip.
复制标题
使用非侵入性傅里叶变换红外光谱技术对人唇进行糖尿病光学筛查。
DOI：
10.1016/j.jpba.2012.12.009
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Yoshida;S.
傅里叶变换中红外光谱（FTIR）技术在临床上尚未应用于糖尿病的诊断。我们试图通过FTIR预测非侵入性血血红蛋白A1c （HbA1c）水平，以便评估和筛查糖尿病。选取20 ~ 80岁住院患者28例，男14例，女14例，有无糖尿病，采用FTIR法对其唇面红外光谱数据进行生化分析。唇表面部分IR峰与血糖、HbA1c水平有显著相关性。在唇部光谱的几个峰中，在1300-1400cm−1附近的峰区分了HbA1c水平较高或较低的基团，表明观察到唇表面有羧基甲基的晚期糖基化终产物。应用偏最小二乘（PLS）回归分析HbA1c水平与唇部FTIR光谱之间的相关性，对受试者的HbA1c值进行了高度显著的预测。一些红外峰与预测HbA1c值的比较有助于有效地去除假阴性数据。本研究提出的FTIR技术对筛查HbA1c水平较高的糖尿病患者是有效的。
The Fourier-transform mid-infrared spectroscopy (FTIR) technique has not been used for diabetes diagnosis so far in clinical practice. We attempted to predict non-invasively blood hemoglobin A1c (HbA1c) levels by FTIR to enable evaluation and screening for diabetes. Twenty eight patients from age 20s to 80s, 14 males and 14 females, with and without diabetes, were examined in hospital as a pilot study, and their biochemical data were analyzed with infrared (IR) spectral data of the lip surface by FTIR spectroscopy. Some IR peaks of lip surface had significant correlations with blood glucose and HbA1c levels. Among several peaks in the spectra of lip, peaks at around 1300–1400cm−1discriminated groups with higher or lower HbA1c levels, suggesting the observation of lip surface advanced glycation end-products with carboxymethyl group. The application of partial least squares (PLS) regression analysis to the correlation between HbA1c levels and lip FTIR spectra resulted in highly significant prediction of HbA1c values for the subjects. Comparison of some IR peaks with predicted HbA1c values served to remove false-negative data effectively. This study with FTIR technique proposed here was effective for screening of diabetes patients with higher HbA1c levels.