Commentary on classic paper in hyperthermic oncology 'Tumour oxygenation is increased by hyperthermia at mild temperatures' by CW Song et al., 1996.
Commentary on classic paper in hyperthermic oncology 'Tumour oxygenation is increased by hyperthermia at mild temperatures' by CW Song et al., 1996.
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CW Song 等人，1996 年对热肿瘤学经典论文“温和温度下的热疗增加肿瘤氧合”的评论。
DOI：
10.1080/02656730902758700
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Corry,PeterM
中科院分区：
文献类型：
--
作者：
Griffin,RobertJ;Corry,PeterM
The paper by Song et al. entitled ‘Tumour oxygenation is increased by hyperthermia at mild temperatures’[1] from the radiation biology laboratory at the University of Minnesota was one of the first basic science studies to support the hypothesis that the clinical gains being seen with thermoradiotherapy in the clinic may be due to reoxygenation of the tumor, and not exclusively due to inhibition of DNA repair or direct heatinduced cytotoxicity [2]. Dr Song and others such as Vaupel, Bicher and Tanaka had previously characterized in detail much of the thermal dose and tumor blood-flow relationships in multiple rodent tumor lines and even patients both in thermotolerant and non-themotolerant situations [3–8]. However, the focus of the prior studies was much less on the benefits of mild temperatures and instead on how we might overcome the physiological reactions of the tumor to increase heat-induced cytotoxicity. By the late 1980s and early 1990s the puzzling realization occurred that clinical hyperthermia was not typically achieving cytotoxic levels and yet was improving treatment outcomes when combined with radiotherapy. This strongly suggested that an augmented blood-flow response to non-vascular damaging thermal treatment was a major influence in these encouraging clinical results.
