Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population
Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population
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CD14 G(-1145)A和C(-159)T多态性与中国汉族人群结核病风险降低的关联
DOI：
10.4238/2012.september.25.11
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发表时间：
2012-01-01
影响因子：
0.4
通讯作者：
Li, J. C.
中科院分区：
文献类型：
--
作者：
Zhao, M. Y.;Xue, Y.;Li, J. C.
虽然CD 14在介导Toll样受体识别结核分枝杆菌的信号中的作用是已知的，但该基因的多态性如何影响结核病的易感性仍不清楚。我们通过对432名中国结核病患者和404名种族匹配的健康对照进行病例对照研究，检测了CD 14基因启动子区-1145和-159位点单核苷酸多态性是否与中国汉族人群结核病相关。通过PCR-DNA测序进行基因分型以鉴定CD 14基因的多态性。C（-159）T多态性中T等位基因的频率（OR = 1.4; 95%CI = 1.148-1.708）和G（-1145）A多态性中G等位基因的频率（OR = 1.512; 95%CI = 1.236-1.849）在病例组均显著高于对照组。C（-159）T多态性中CC、CT基因型频率及AA、AG基因型频率在病例组均低于对照组。根据我们的研究结果，我们得出结论，G（-1145）A和C（-159）T多态性与中国汉族人群结核病的风险降低。
Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a Chinese Han population in a case-control study of 432 Chinese patients with tuberculosis and 404 ethnically matched healthy controls. Genotyping was performed to identify polymorphisms of the CD14 gene by PCR-DNA sequencing. Both the frequency of allele T in the C(-159) T polymorphism (odds ratio (OR) = 1.4; 95% confidence interval (95%CI) = 1.148-1.708) and allele G in the G(-1145) A polymorphism (OR = 1.512; 95%CI = 1.236-1.849) were significantly more frequent in cases than in controls. The frequencies of genotypes CC and CT in the C(-159)T polymorphism, as well as the frequencies of genotypes AA and AG, were lower in cases than in controls. Based on our results, we conclude that G(-1145) A and C(-159) T polymorphisms of CD14 are associated with decreased risk for the development of tuberculosis in the Chinese Han population.