Emerging roles of protein kinases in microglia‐mediated neuroinflammation
Emerging roles of protein kinases in microglia‐mediated neuroinflammation
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DOI：
10.1016/j.bcp.2017.06.137
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发表时间：
2017-07
影响因子：
5.8
通讯作者：
Sun-Hwa Lee;K. Suk
中科院分区：
文献类型：
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作者：
Sun-Hwa Lee;K. Suk
神经炎症是由中枢神经胶质细胞、神经元、外周免疫细胞、血脑屏障以及这些细胞分泌的炎症介质介导的。神经炎症与中风和神经退行性疾病如阿尔茨海默病、帕金森病、多发性硬化症和肌萎缩侧索硬化症有关。蛋白激酶已成为当前药理学研究中开发最多的治疗靶点之一，特别是在癌症和炎症的研究中。迄今为止，美国食品和药物管理局已经批准了32种小分子蛋白激酶抑制剂用于治疗癌症和炎症。然而，目前还没有针对神经炎症和/或神经退行性疾病的有效药物。最近的研究表明，几种蛋白激酶是神经炎症和/或神经退行性疾病的重要药物靶点。在这里，我们回顾新出现的蛋白激酶可能参与神经炎症和随后的神经退行性疾病。
Neuroinflammation is mediated by resident central nervous system glia, neurons, peripherally derived immune cells, blood-brain barrier, and inflammatory mediators secreted from these cells. Neuroinflammation has been implicated in stroke and neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. Protein kinases have been one of the most exploited therapeutic targets in the current pharmacological research, especially in studies on cancer and inflammation. To date, 32 small-molecule protein kinase inhibitors have been approved by the United States Food and Drug Administration for the treatment of cancer and inflammation. However, there is no drug effectively targeting neuroinflammation and/or neurodegenerative diseases. Recent studies have advanced several protein kinases as important drug targets in neuroinflammation and/or neurodegenerative diseases. Here, we review emerging protein kinases potentially involved in neuroinflammation and subsequent neurodegenerative diseases.