The reuniens and rhomboid nuclei: neuroanatomy, electrophysiological characteristics and behavioral implications.
The reuniens and rhomboid nuclei: neuroanatomy, electrophysiological characteristics and behavioral implications.
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DOI：
10.1016/j.pneurobio.2013.08.006
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发表时间：
2013-12
影响因子：
6.7
通讯作者：
Vertes RP
中科院分区：
文献类型：
--
作者：
Cassel JC;Pereira de Vasconcelos A;Loureiro M;Cholvin T;Dalrymple-Alford JC;Vertes RP
位于丘脑腹侧中线的连合核和菱形核长期以来被认为对皮质具有非特异性影响，而其他证据表明它们影响与光周期，饥饿，压力或焦虑有关的行为。我们总结了最近的解剖，电生理和行为的证据，这些核团也影响认知过程。本文第一部分介绍了连合核和菱形核与内侧前额叶皮层和海马的相互联系。这些结构之间的连接模式是一致的想法，这些腹侧中线核代表了一个节点枢纽，以影响前额叶海马的相互作用。第二部分描述了刺激或阻断丘脑腹侧中线对皮层和海马电生理活动的影响。最后一部分总结了最近的文献支持新兴的观点，即联合核和菱形核可能有助于学习，记忆巩固和行为灵活性，除了一般行为和代谢方面。
The reuniens and rhomboid nuclei, located in the ventral midline of the thalamus, have long been regarded as having non-specific effects on the cortex, while other evidence suggests that they influence behavior related to the photoperiod, hunger, stress or anxiety. We summarise the recent anatomical, electrophysiological and behavioral evidence that these nuclei also influence cognitive processes. The first part of this review describes the reciprocal connections of the reuniens and rhomboid nuclei with the medial prefrontal cortex and the hippocampus. The connectivity pattern among these structures is consistent with the idea that these ventral midline nuclei represent a nodal hub to influence prefrontalhippocampal interactions. The second part describes the effects of a stimulation or blockade of the ventral midline thalamus on cortical and hippocampal electrophysiological activity. The final part summarizes recent literature supporting the emerging view that the reuniens and rhomboid nuclei may contribute to learning, memory consolidation and behavioral flexibility, in addition to general behavior and aspects of metabolism.