Is Apparent Diffusion Coefficient Associated with Clinical Risk Scores for Prostate Cancers that Are Visible on 3-T MR Images ?
Is Apparent Diffusion Coefficient Associated with Clinical Risk Scores for Prostate Cancers that Are Visible on 3-T MR Images ?
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DOI：
10.1148/radiol.10100667
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发表时间：
2011-02-01
期刊：
影响因子：
19.7
通讯作者：
Choyke, Peter L.
中科院分区：
文献类型：
--
作者：
Turkbey, Baris;Shah, Vijay P.;Choyke, Peter L.
目的：以MR成像/经直肠超声（US）融合引导活检作为参考，研究3 T下弥散加权（DW）磁共振（MR）成像得出的表观弥散系数（ADC）是否与MR图像上可见肿瘤患者的前列腺癌临床风险相关。（中位年龄60岁;中位血清前列腺特异性抗原值6.3 ng/mL），在3-T MR成像期间使用直肠内线圈进行DW成像，并获得每例患者的知情同意书。患者接受靶向MR成像/经直肠US融合引导前列腺活检。癌性靶肿瘤的平均ADC与Gleason和D 'Amico临床风险评分相关。采用线性判别分析和受试者工作特征分析确定肿瘤的真实危险组率和平均ADC值对D 'Amico临床危险评分的预测价值。结果：外周区肿瘤的平均ADC值与Gleason评分呈显著负相关（P = 0.003;斯皮尔曼rho = -0.60）和D 'Amico临床风险评分（P <0.0001;斯皮尔曼rho = -0.69）。ADC值对中、高、低临床危险度的外周带肿瘤的分类正确率为0.73。结论：ADC值与Gleason和D 'Amico临床危险度评分呈显著负相关。因此，ADC可能有助于预测前列腺癌的侵袭性。（C）RSNA，2010年补充材料：http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100667/-/DC1
Purpose: To investigate whether apparent diffusion coefficients (ADCs) derived from diffusion-weighted (DW) magnetic resonance (MR) imaging at 3 T correlate with the clinical risk of prostate cancer in patients with tumors that are visible on MR images, with MR imaging/transrectal ultrasonography (US) fusion-guided biopsy as a reference.Materials and Methods: Forty-eight consecutive patients (median age, 60 years; median serum prostate-specific antigen value, 6.3 ng/mL) who underwent DW imaging during 3-T MR imaging with an endorectal coil were included in this retrospective institutional review board-approved study, and informed consent was obtained from each patient. Patients underwent targeted MR imaging/transrectal US fusion-guided prostate biopsy. Mean ADCs of cancerous target tumors were correlated with Gleason and D'Amico clinical risk scores. The true risk group rate and predictive value of the mean ADC for classifying a tumor by its D'Amico clinical risk score was determined by using linear discriminant and receiver operating characteristic analyses.Results: A significant negative correlation was found between mean ADCs of tumors in the peripheral zone and their Gleason scores (P = .003; Spearman rho = -0.60) and D'Amico clinical risk scores (P < .0001; Spearman rho = -0.69). ADC was found to distinguish tumors in the peripheral zone with intermediate to high clinical risk from those with low clinical risk with a correct classification rate of 0.73.Conclusion: There is a significant negative correlation between ADCs and Gleason and D'Amico clinical risk scores. ADCs may therefore be useful in predicting the aggressiveness of prostate cancer. (C)RSNA, 2010 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100667/-/DC1