MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression.
MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression.
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MiR-125a-5p 通过抑制 IL-6R 和 STAT3 表达降低 Treg 细胞对 IL-6 介导的转化的敏感性
DOI：
10.1038/srep14615
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发表时间：
2015-10-01
影响因子：
4.6
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Li D;Kong C;Tsun A;Chen C;Song H;Shi G;Pan W;Dai D;Shen N;Li B
转录因子FOXP 3对调节性T细胞（Treg）的分化和功能至关重要。已确定转录因子加塔-3在炎性条件下在Treg细胞中被诱导。加塔-3稳定FOXP 3水平以避免Treg细胞分化为炎性样T细胞。IL-6信号通路影响Treg细胞对不稳定性的敏感性。加塔-3调节FOXP 3的机制及其与IL-6通路的关系尚不清楚。在这里，我们报告了miR-125 a-5 p如何在调节IL-6对Treg细胞的转化中发挥重要作用。在稳态条件下，miR-125 a-5 p在Treg细胞中的表达较低，并且可以被加塔-3诱导以抑制IL-6 R和STAT 3的表达。这一发现揭示了GATA 3/miR-125 a-5 p/IL-6 R和STAT 3/FOXP 3调节通路，其决定了Treg细胞如何响应富含IL-6的炎症条件。
The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into inflammatory-like T cells. The IL-6 signal pathway influences the sensitivity of Treg cells towards instability. The mechanism of GATA-3 in regulating FOXP3 and its relation to the IL-6 pathway remains unclear. Here we report how miR-125a-5p plays an important role in regulating the conversion of Treg cells by IL-6. miR-125a-5p expression is low in Treg cells under steady state conditions and can be induced by GATA-3 to inhibit the expression of IL-6R and STAT3. This finding reveals a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells respond to inflammatory IL-6-rich conditions.