Breaking Barriers New Insights into Airway Epithelial Barrier Function in Health and Disease
Breaking Barriers New Insights into Airway Epithelial Barrier Function in Health and Disease
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DOI：
10.1165/rcmb.2013-0541rt
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发表时间：
2014-05-01
影响因子：
6.4
通讯作者：
Georas, Steve N.
中科院分区：
文献类型：
--
作者：
Rezaee, Fariba;Georas, Steve N.
上皮通透性是粘膜炎症的标志，但涉及的分子机制仍然知之甚少。上皮屏障的一个关键组成部分是相邻细胞之间形成的顶端连接复合体。顶端连接复合物由紧密连接和粘附连接组成，并通过许多接头蛋白连接到细胞骨架。虽然上皮细胞之间紧密连接和粘附连接的存在早已被认识，但近年来，我们对连接复合物组装和拆卸的分子调控的理解有了重大进展。在这里，我们回顾了目前的想法，在气道上皮细胞的顶端连接复合体的结构和功能，强调相关的囊性纤维化和哮喘的翻译方面。迄今为止，大多数工作都是使用细胞培养模型进行的，但成像技术的技术进步表明，我们即将在气道疾病的生理模型这一领域取得重要的新突破。
Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms involved remain poorly understood. A key component of the epithelial barrier is the apical junctional complex that forms between neighboring cells. Apical junctional complexes are made of tight junctions and adherens junctions and link to the cellular cytoskeleton via numerous adaptor proteins. Although the existence of tight and adherens junctions between epithelial cells has long been recognized, in recent years there have been significant advances in our understanding of the molecular regulation of junctional complex assembly and disassembly. Here we review the current thinking about the structure and function of the apical junctional complex in airway epithelial cells, emphasizing the translational aspects of relevance to cystic fibrosis and asthma. Most work to date has been conducted using cell culture models, but technical advancements in imaging techniques suggest that we are on the verge of important new breakthroughs in this area in physiological models of airway diseases.