The art of compartment design for synthetic catalysts
The art of compartment design for synthetic catalysts
复制标题
合成催化剂的隔室设计艺术
DOI：
10.1039/d2qi02332f
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发表时间：
2023
影响因子：
7
通讯作者：
Diaconescu, Paula L.
中科院分区：
文献类型：
--
作者：
Davis, Ashton R.;Liu, Chong;Diaconescu, Paula L.
作为一种在催化转化中引入额外控制水平的方法，将合成催化剂限制在纳米级隔间中已受到越来越多的关注。在隔室内进行反应在生物学中是普遍存在的，最近的注意力已经转向将相同的原理应用于合成系统。该观点试图阐明隔间设计原理并找出当前方法的缺点。我们首先使用酶作为生物区室的示例模型系统，推断指导原则，并将其应用于有机金属催化剂。然后将结构和空间作为分区中的总体设计原则进行探索。最后，提出了未来方向的建议。区室化有潜力成为一种强大的综合工具，但是，需要进一步努力理解发挥作用的基本原理。在此，区室化被提出作为仿生学指导的重要合成策略。
Confining synthetic catalysts in nanoscopic compartments has been gaining traction as a method to introduce additional levels of control in catalytic transformations. Running reactions inside of compartments is ubiquitous in biology, and recent attention has turned toward applying the same principles to synthetic systems. This perspective attempts to elucidate compartment design principles and identify shortcomings of current methodologies. We start by using enzymes as an exemplar model system for biological compartments, extrapolate guiding principles, and apply them to organometallic catalysts. Structure and space are then explored as overarching design principles at work in compartmentalization. Finally, suggestions for future directions are provided. Compartmentalization has the potential to become a powerful synthetic tool, however, further work in understanding the fundamental principles at play is required. Herein, compartmentalization is presented as an important synthetic strategy guided by biomimicry.