Physicochemical profiling: overview of the screens.
Physicochemical profiling: overview of the screens.
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DOI：
10.1016/j.ddtec.2004.08.011
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Di, L
中科院分区：
文献类型：
--
作者：
Kerns, E H;Di, L
物理化学筛选越来越多地用于药物发现，以提供对影响ADME的关键特性的早期了解。他们还确保发现实验的计划和解释是正确的。讨论的主要物理化学性质是：完整性、pKa、亲脂性、溶解度和渗透性。不同的小组可能会采用文献方法或发展自己的方法。商业工具也可用于这些属性，使团体能够迅速为其组织提供数据。
Physicochemical screens are increasingly used in drug discovery to provide an early understanding of key properties that affect ADME. They also insure that discovery experiments are planned and interpreted correctly. Key physicochemical properties discussed are: integrity, pKa, lipophilicity, solubility and permeability. Various groups might implement literature methods or develop their own. Commercial instruments are also available for these properties to allow groups to rapidly provide data for their organizations.: