Depression and the risk of coronary heart disease in the Normative Aging Study.
Depression and the risk of coronary heart disease in the Normative Aging Study.
复制标题
规范老龄化研究中的抑郁症和冠心病风险。
DOI：
10.1016/s0002-9149(98)00491-3
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Sparrow,D
中科院分区：
文献类型：
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作者：
Sesso,HD;Kawachi,I;Vokonas,PS;Sparrow,D
越来越多的证据支持症状性抑郁症与冠心病（CHD）风险之间的关联，尽管没有一项研究比较了多种抑郁量表。我们假设，从不同的抑郁量表评估的症状性抑郁水平较高与冠心病的风险。我们在一项老年男性前瞻性队列研究中研究了这种关系。1986年，共有1,305名未被诊断为冠心病的男性完成了修订的明尼苏达多相人格调查表（MMPI-2）。我们对MMPI-2D、MMPI-2DEP和症状自评量表（SCL-90）抑郁量表的得分进行了分类。在平均7.0年的随访中，发生了110例冠心病事件，包括30例非致命性心肌梗死，20例致命性冠心病，60例心绞痛。与报告抑郁水平最低的男性相比，抑郁水平最高的男性有冠心病事件的多变量校正相对风险（总CHD和心绞痛）为1.46（95%置信区间0.83 - 2.57），2.07 MMPI-2D、MMPI-2DEP和SCL-90量表的平均得分分别为1.73（95%可信区间1.13 ~ 3.81）和1.73（95%可信区间0.97 ~ 3.10）。根据每个抑郁量表，每个CHD亚型获得相似的RR。我们发现MMPI-2 DEP量表测量的抑郁水平与心绞痛（趋势p值为0.039）和CHD（趋势p值为0.016）的发病率之间存在较强的剂量反应关系。在老年男性中，通过3种抑郁量表中的任何一种测量的症状性抑郁可能与CHD的风险呈正相关。
Increasing evidence supports an association between symptomatic depression and the risk of coronary heart disease (CHD), although no single study has compared multiple depression scales. We hypothesized that higher levels of symptomatic depression assessed from different depression scales were associated with the risk of CHD. We examined this relation in the Normative Aging Study, a prospective cohort of older men. A total of 1,305 men free of diagnosed CHD in 1986 completed the revised Minnesota Multiphasic Personality Inventory (MMPI-2). We categorized scores for the MMPI-2 D, MMPI-2 DEP, and Symptom Checklist-90 (SCL-90) depression scales. During an average 7.0 years of follow-up, 110 cases of incident CHD occurred, including 30 cases of nonfatal myocardial infarction, 20 cases of fatal CHD, and 60 cases of angina pectoris. Compared with men reporting the lowest level of depression, men in the highest level of depression had multivariate-adjusted relative risks of incident CHD (total CHD and angina) of 1.46 (95% confidence interval 0.83 to 2.57), 2.07 (95% confidence interval 1.13 to 3.81), and 1.73 (95% confidence interval 0.97 to 3.10) for the MMPI-2 D, MMPI-2 DEP, and SCL-90 scales, respectively. Similar RRs were obtained for each CHD subtype according to each depression scale. We found strong dose-response relations between level of depression measured by the MMPI-2 DEP scale and incidence of both angina pectoris (p value for trend, 0.039) and CHD (p value for trend, 0.016). Among older men, symptomatic depression measured by any of 3 depression scales may be positively associated with the risk of CHD.