Chiral information harvesting in dendritic metallopeptides.
Chiral information harvesting in dendritic metallopeptides.
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DOI：
10.1038/nchem.1146
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发表时间：
2011-11
期刊：
影响因子：
21.8
通讯作者：
N. Ousaka;Y. Takeyama;Hiroki Iida;E. Yashima
中科院分区：
文献类型：
--
作者：
N. Ousaka;Y. Takeyama;Hiroki Iida;E. Yashima
立体化学信息的远程通信在生物系统中很常见，特别是在酶催化反应中。在这里，我们报告的远程控制的动态手性的金属中心，协调由2，2 ′-联吡啶配体轴承动态螺旋寡肽。寡肽的螺旋手性由远离金属的立体中心控制。我们表明，当使用的手性和非手性肽配体的混合物，无论是金属中心的手性和非手性寡肽螺旋显着放大。扩增机制依赖于几个步骤的手性诱导，首先从一个单一的手性肽的螺旋通过螺旋桨手性在金属中心的诱导寡肽，然后在非手性寡肽的螺旋手性诱导。
Long-range communication of stereochemical information is common in biological systems, particularly in enzyme-catalysed reactions. Here, we report the remote control of the dynamic chirality of metal centres, coordinated by 2,2′-bipyridine ligands bearing dynamic helical oligopeptides. The helical chirality of the oligopeptides is controlled by a stereocentre remote from the metal. We show that when a mixture of chiral and achiral peptide ligands is used, both the chirality of the metal centre and that of the achiral oligopeptide helices are significantly amplified. The amplification mechanism relies on several steps of chirality induction, first from a single chiral peptide to the helicity of an oligopeptide through the induction of propeller chirality at the metal centre, then on to induction of helical chirality in an achiral oligopeptide.