Dietary fat intake and risk of coronary heart disease: the Strong Heart Study
Dietary fat intake and risk of coronary heart disease: the Strong Heart Study
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DOI：
10.1093/ajcn/84.4.894
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发表时间：
2006-10-01
影响因子：
7.1
通讯作者：
Lee, Elisa T.
中科院分区：
文献类型：
--
作者：
Xu, Jiaqiong;Eilat-Adar, Sigal;Lee, Elisa T.
背景资料：以往关于膳食脂肪摄入量与冠心病发病率之间关系的研究结果不一致。目的：本研究的目的是在强心研究中检验美国印第安人膳食脂肪摄入量与冠心病发病率之间的关系。设计：共有2938名年龄在47-79岁之间，在第二次检查（1993-1995年）时没有CHD的参与者接受了CHD、非致死性CHD和致死性CHD事件的检查和随访，直至2002年12月31日。饮食摄入量通过24小时饮食回忆进行评估，并以能量百分比计算。结果：参与者被随访平均（+/- SD）7.2 +/- 2.3年。在随访期间，确定了436例CHD事件（298例非致死性CHD和138例致死性CHD事件）。总脂肪、饱和脂肪酸或单不饱和脂肪酸摄入量最高四分位数的47-59岁参与者的CHD死亡率高于摄入量最低四分位数的参与者[风险比（95%CI）：在控制混杂因素后，分别为3.57（1.21，10.49），5.17（1.64，16.36）和3.43（1.17，10.04）。这些协会没有观察到那些年龄在60-79岁。结论：总脂肪，饱和脂肪酸和单不饱和脂肪酸的摄入量是强有力的预测冠心病死亡率在47-59岁的美国印第安人，独立于其他既定的冠心病危险因素。对于美洲印第安人来说，在生命早期减少脂肪摄入量以降低死于冠心病的风险可能是明智的。
Background: The results of previous studies on the association between dietary fat intake and coronary heart disease (CHD) incidence are inconsistent.Objective: The aim of this study was to examine the association between dietary fat intake and CHD incidence in American Indians in the Strong Heart Study.Design: A total of 2938 participants aged 47-79 y and free of CHD at the second examination (1993-1995) were examined and followed for CHD, nonfatal CHD, and fatal CHD events to 31 December 2002. Dietary intake was assessed by using a 24-h diet recall and was calculated as percentages of energy.Results: Participants were followed for a mean (+/- SD) of 7.2 +/- 2.3 y. During follow-up, 436 incident CHD cases (298 nonfatal CHD and 138 fatal CHD events) were ascertained. Participants aged 47-59 y in the highest quartile of intake of total fat, saturated fatty acids, or monounsaturated fatty acids had higher CHD mortality than did those in the lowest quartile [hazard ratio (95% Cl): 3.57 (1.21, 10.49), 5.17 (1.64, 16.36), and 3.43 (1.17, 10.04), respectively] after confounders were controlled for. These associations were not observed for those aged 60-79 y.Conclusions: Total fat, saturated fatty acid, and monounsaturated fatty acid intake were strong predictors of CHD mortality in American Indians aged 47-59 y, independent of other established CHD risk factors. It may be prudent for American Indians to reduce their fat intake early in life to reduce the risk of dying from CHD.