LEUKOCYTE COUNTS AND CORONARY HEART-DISEASE IN A JAPANESE COHORT
LEUKOCYTE COUNTS AND CORONARY HEART-DISEASE IN A JAPANESE COHORT
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DOI：
10.1093/oxfordjournals.aje.a113434
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
HAMILTON, HH
中科院分区：
文献类型：
--
作者：
PRENTICE, RL;SZATROWSKI, TP;HAMILTON, HH
1958-1974年间，广岛和长崎居民的冠心病发病率与平均2年前的总白细胞计数显著相关（P = 0.01）。相对风险，作为白细胞计数的函数，似乎不依赖于性别或吸烟状况，但65岁以下的受试者可能比老年人更大。本研究首次探讨了与冠心病发病率相关的白细胞计数和百分比差异。中性粒细胞计数和嗜酸性粒细胞计数与冠心病发病率有显著相关性，同时也与单核细胞计数有关。提到了这种关联的可能的免疫病理学基础。然而，对于其他研究来说，确认这些关系将是很重要的，因为目前的数据不允许人们清楚地表明，在特定的白细胞总数下，相对风险取决于不同的白细胞分数。与吸烟习惯和血清胆固醇水平等已知危险因素相比，现有数据还不确定白细胞计数在冠心病危险指标中的独立性。
Coronary heart disease incidence during 1958-1974, in a cohort of Hiroshima and Nagasaki residents, related significantly (P = 0.01) to total leukocyte count, taken an average of 2 yr earlier. Relative risks, as a function of leukocyte count, did not appear to depend on sex or cigarette smoking status, but may be larger for subjects less than 65 yr of age than for older persons. This study examines, for the 1st time, differential leukocyte counts and percentages in relation to coronary heart disease incidence. Both neutrophil count and eosinophil count significantly relate to coronary heart disease incidence, while there is also a suggestion for a relationship with monocyte count. A possible immunopathologic basis for such associations is mentioned. It will be important for other studies to confirm these relationships, however, as the present data do not allow one to clearly show the relative risk, at a specified total leukocyte count, to depend on the differential leukocyte fractions. Available data also leave uncertainty concerning the independence of leukocyte counts in the specification of coronary heart disease risk, relative to such known risk factors as ciagrette smoking habits and serum cholesterol levels.