Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus
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DOI：
10.1001/jama.286.19.2421
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发表时间：
2001-11-21
影响因子：
120.7
通讯作者：
Manson, JE
中科院分区：
文献类型：
--
作者：
Solomon, CG;Hu, FB;Manson, JE
背景虽然月经过少与胰岛素抵抗和葡萄糖耐受不良有关，但尚不清楚月经过少是否是未来2型糖尿病（DM）风险增加的标志。目的前瞻性评估月经周期长或高度不规则的女性患2型DM的风险。一项前瞻性观察性队列研究。参与者共有101073名妇女，她们没有糖尿病的既往病史，并在基线（1989年）调查表上报告了她们在18至22岁时通常的月经周期模式。主要结果测量糖尿病的事件报告，结果在564333人年的随访中，有507例2型糖尿病患者。与通常周期长度为26至31天的女性相比在18至22岁的女性中，月经周期长度为40天或更长或太不规则而无法估计的女性患2型糖尿病的相对风险（RR）为2.08（95%置信区间[CI]，1.62-2.66），调整18岁时的体重指数和其他几个潜在的混杂变量。肥胖女性中与月经周期长或高度不规则相关的2型糖尿病的RR更高，但在非肥胖女性中也有所增加（18岁时的体重指数为
Context Although oligomenorrhea has been associated cross-sectionally with insulin resistance and glucose intolerance, it is not known whether oligomenorrhea is a marker for increased future risk of type 2 diabetes mellitus (DM).Objective To prospectively assess risk of type 2 DM in women with a history of long or highly irregular menstrual cycles.Design and Setting The Nurses' Health Study II, a prospective observational cohort study.Participants A total of 101073 women who had no. prior history of DM and who reported their usual menstrual cycle pattern at age 18 to 22 years on the baseline (1989) questionnaire.Main Outcome Measure Incident reports of DM, with follow-up through 1997, compared among women categorized by menstrual cycle length (5 categories).Results During 564333 person-years of follow-up, there were 507 cases of type 2 DM. Compared with women with a usual cycle length of 26 to 31 days (referent category) at age 18 to 22 years, the relative risk (RR) of type 2 DM among women with a menstrual cycle length that was 40 days or more or was too irregular to estimate was 2.08 (95% confidence interval [CI], 1.62-2.66), adjusting for body mass index at age 18 years and several other potential confounding variables. The RR of type 2 DM associated with long or highly irregular menstrual cycles was greater in obese women, but was also increased in nonobese women (at body mass indexes at age 18 years of