Prostaglandin biology
Prostaglandin biology
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DOI：
10.1016/s0889-8553(05)70217-x
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发表时间：
2001-12-01
影响因子：
3.7
通讯作者：
Crofford, LJ
中科院分区：
文献类型：
--
作者：
Crofford, LJ
前列腺素（pg）是生理功能和病理反应的介质。PG活性的多样性是通过细胞和组织特异性产生不同的稳定PG，连接不同细胞内信号通路的多个PG受体，以及诱导显著增加局部PG生成的酶的PG生成途径来实现的。本文将对PG的产生机制和作用进行综述。剖析这些生化和分子途径可以更好地理解PG产生抑制剂的临床药理学，并可能允许开发可应用于特定临床情况的治疗药物，同时保留PG在正常生理中发挥的作用。
Prostaglandins (PGs) are mediators of physiologic functions and pathologic responses. The diversity of PG activities is achieved by cell and tissue-specific generation of different stable PGs, multiple PG receptors linked to different intracellular signaling pathways, and PG production pathways involving enzymes that are induced to dramatically increase local PG production. This article will review mechanisms of PG production and action. Dissecting these biochemical and molecular pathways provides greater understanding of the clinical pharmacology of available inhibitors of PG production and may allow development of therapeutic agents that can be applied to specific clinical situations, while preserving PGs that play a role in normal physiology.