Migratory neural crest-like cells form body pigmentation in a urochordate embryo
Migratory neural crest-like cells form body pigmentation in a urochordate embryo
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DOI：
10.1038/nature02975
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发表时间：
2004-10-07
期刊：
影响因子：
64.8
通讯作者：
Yamamoto, Y
中科院分区：
文献类型：
--
作者：
Jeffery, WR;Strickler, AG;Yamamoto, Y
神经脊是脊椎动物胚胎中许多不同细胞类型的来源，在其他脊索动物中尚未发现(1-3)。因此，目前的观点认为，神经脊细胞是脊椎动物的创新(4-7)。在这里，我们描述了一个类似神经脊细胞的迁移细胞群在海鞘中。用重要的亲脂染料DII标记胚胎和幼虫，使我们能够检测到从神经管出来的细胞，迁移到体壁和虹吸原基，然后分化为色素细胞。这些细胞表达脊椎动物神经脊细胞的HNK-1抗原和Zic基因标志。这些结果表明，在尾索动物体内存在一些具有神经脊细胞特征的迁移细胞。因此，我们提出了一个假设，即神经脊的进化始于从中枢神经系统释放的迁移细胞，从而在尾索动物和脊椎动物的共同祖先中产生身体色素沉着。这些细胞可能已经获得了额外的功能，或者被其他类型的细胞连接起来，产生了脊椎动物神经脊典型的各种衍生品。
The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates(1-3). Current opinion therefore holds that neural crest cells were a vertebrate innovation(4-7). Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteinascidia turbinata. Labelling of embryos and larvae with the vital lipophilic dye DiI enabled us to detect cells that emerge from the neural tube, migrate into the body wall and siphon primordia, and subsequently differentiate as pigment cells. These cells express HNK-1 antigen and Zic gene markers of vertebrate neural crest cells. The results suggest that migratory cells with some of the features of neural crest cells are present in the urochordates. Thus, we propose a hypothesis for neural crest evolution beginning with the release of migratory cells from the CNS to produce body pigmentation in the common ancestor of the urochordates and vertebrates. These cells may have gained additional functions or were joined by other cell types to generate the variety of derivatives typical of the vertebrate neural crest.