Correlation of diffusion tensor imaging with executive function measures after early childhood traumatic brain injury
Correlation of diffusion tensor imaging with executive function measures after early childhood traumatic brain injury
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DOI：
10.3233/prm-2009-0093
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发表时间：
2009-01-01
影响因子：
1.9
通讯作者：
Holland, Scott K.
中科院分区：
文献类型：
--
作者：
Kurowski, Brad;Wade, Shari L.;Holland, Scott K.
目的：检查早期儿童（3-7 岁）创伤性脑损伤 (TBI) 后弥散张量成像 (DTI) 分数各向异性 (FA) 与执行功能 (EF) 和注意力测量的关系。设计：探索性相关性和比较研究。地点：儿童医院门诊设施。参与者：9 名有 TBI 病史的儿童（年龄 = 7.89 +/- 1.00 岁；格拉斯哥昏迷量表 (GCS) = 10.11 +/- 4.68）与 12 名 OI 儿童（年龄 = 7.51 +/- 0.95）进行了比较。所有儿童均在受伤后至少 12 个月进行评估。主要结果测量：各个感兴趣区域 (ROI) 的 FA、EF 和注意力测量。结果：主要在额叶白质轨迹中的 FA 值与 EF 测量相关。抑制和转换的单独任务与双侧额叶的 FA 显着相关。结合抑制和转换的任务与左额叶的 FA 值显着相关。注意力任务与右额叶白质和上纵束的 FA 值呈负相关。 结论：幼儿 TBI 后晚期 FA 测量和 EF 测量之间的关联表明，持续的白质变化，尤其是额叶白质，可能提供 EF 缺陷的指标。
Objective: Examine relationships of diffusion tensor imaging (DTI) fractional anisotropy (FA) to executive function (EF) and attention measures following early childhood (3-7 years) traumatic brain injury (TBI).Design: Exploratory correlation and comparison study.Setting: Children's hospital outpatient facilities.Participants: 9 children with a history of TBI (age = 7.89 +/- 1.00 years; Glasgow Coma Scale (GCS) = 10.11 +/- 4.68) were compared to 12 children with OI (age = 7.51 +/- 0.95). All children were at least 12 months post injury at time of evaluation.Main Outcome Measures: FA in various regions of interest (ROI), EF and attention measures.Results: FA values primarily in the frontal white matter tracks correlated with EF measures. Separate tasks of inhibition and switching correlated significantly with FA in bilateral frontal lobes. Tasks combining both inhibition and switching correlated significantly with FA values in the left frontal lobe. Tasks of attention negatively correlated with FA values in the right frontal white matter and the superior longitudinal fasciculus.Conclusions: Associations between late measurement of FA and EF measures following early childhood TBI suggest that persistent white matter changes, especially in the frontal white matter, may provide an index of EF deficits.