Esophageal cancer: a review and update.
Esophageal cancer: a review and update.
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DOI：
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发表时间：
2006-06
影响因子：
4
通讯作者：
John C. Layke;P. Lopez
中科院分区：
文献类型：
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作者：
John C. Layke;P. Lopez
尽管食管癌的治疗已经取得了显著的进步，但这种侵袭性恶性肿瘤通常表现为局部晚期疾病，预后不良。尽管在癌前病变的检测，更新的预防策略，更有效的联合治疗的发展，食管癌的总体发病率有所上升。食管癌的发生与幽门螺杆菌感染、胃食管反流病、吸烟和酗酒之间存在明显的相关性。然而，尽管质子泵抑制剂和根除H。幽门螺杆菌，离开医学界寻找更多的答案。食管腺癌和肥胖之间存在潜在联系。食管癌的常见症状是吞咽困难、吞咽痛和进行性体重减轻。对有这些症状的患者的初步评估是通过双对比钡剂食管造影来进行的。治疗方式包括手术、化疗、放射治疗或多种方式的组合。预防策略包括戒烟和戒酒。
Although significant advancements have been made in the treatment of esophageal cancer, this aggressive malignancy commonly presents as locally advanced disease with a poor prognosis. Despite improvements in the detection of premalignant pathology, newer preventative strategies, and the development of more effective combination therapies, the overall incidence of esophageal carcinomas has risen. A clear association has been established between the development of esophageal cancer and Helicobacter pylori infection, gastroesophageal reflux disease, smoking, and heavy alcohol use. However, the growing number of newly diagnosed esophageal adenocarcinomas, despite widespread treatments with proton pump inhibitors and the eradication of H. pylori, leaves the medical community searching for more answers. There is a potential link between esophageal adenocarcinoma and obesity. Common presenting symptoms of esophageal cancer are dysphagia, odynophagia, and progressive weight loss. The initial assessment for patients with these symptoms is made with double-contrast barium esophagraphy. Treatment modalities include surgery, chemotherapy, radiation therapy, or a combination of modalities. Prevention strategies include smoking and alcohol cessation.