The Development and Structure of the Ventricles in the Human Heart
The Development and Structure of the Ventricles in the Human Heart
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DOI：
10.1007/s00246-009-9390-9
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Anderson, Robert H.
中科院分区：
文献类型：
--
作者：
Henderson, Deborah J.;Anderson, Robert H.
在过去的十年里，关于脑室的起源和发展已经了解了很多。然而，大多数新信息(如果不是全部的话)都来自对老鼠心脏的研究。这些信息中的大部分还没有被那些研究心脏功能或诊断先天畸形心脏的人吸收。然而，最近的研究提供的证据，特别是如果它能被证明与人类发展相关的话，与这些主题非常相关。例如，关于每个心室如何获得其入口和出口组件的知识，以及可用于人类发育的信息(Lamers等人，循环86：1194-1205,1992)，为理解先天性心脏畸形，特别是那些依赖于功能性单心室循环的先天性心脏畸形提供了坚实的基础(Jacobs和Anderson，Medicol Young 16(Suppl 1)：3-8,2006)。对于理解所谓的室壁致密化不全的基础，对脑室发育的认识也很重要，因为这一知识将阐明室壁致密的成分是由发育早期所见的最初广泛的小梁区的固结所产生的，还是由致密心肌的缺陷形成和/或成熟所产生的(Anderson，EUR心脏J 29：10-11,2008)。了解心肌细胞堆积在室壁致密成分中的机制将有助于阐明聚集的心肌细胞的结构安排，这是一个最近相当感兴趣的话题。这篇综述讨论了所有这些话题。
Over the past decade, much has been learned concerning the origin and development of the ventricles. However, most, if not all, of the new information has come from study of the mouse heart. Most of this information has yet to be assimilated by those who study ventricular function or diagnose congenitally malformed hearts. Nevertheless, the evidence available from recent studies, particularly if it can be shown relevant to human development, is remarkably pertinent to these topics. For example, knowledge of how each ventricle derives its inlet and outlet components, information available for human development (Lamers et al., Circulation 86:1194-1205, 1992), provides a firm foundation for understanding congenital cardiac malformations, particularly those dependent on a functionally univentricular circulation (Jacobs and Anderson, Cardiol Young 16(Suppl 1):3-8, 2006). Appreciation of ventricle development also is important with regard to understanding the basis of so-called ventricular noncompaction because this knowledge will elucidate whether the compact component of the ventricular walls is produced by consolidation of the initially extensive trabecular zone seen during early development or by defective formation and/or maturation of the compact myocardium (Anderson, Eur Heart J 29:10-11, 2008). Knowledge concerning the mechanism whereby ventricular myocytes are packed within the compact component of the ventricular walls then will help clarify the architectural arrangement of the aggregated myocytes, a topic of considerable recent interest. This review discusses all these topics.