Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women -: A comparison of World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation Definitions
Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women -: A comparison of World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation Definitions
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DOI：
10.2337/dc06-1857
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发表时间：
2007-04-01
期刊：
影响因子：
16.2
通讯作者：
Kuller, Lewis H.
中科院分区：
文献类型：
--
作者：
Raikkonen, Katri;Matthews, Karen A.;Kuller, Lewis H.
目的-我们评估是否与心血管疾病和2型糖尿病相关的社会心理因素预测前瞻性的风险代谢综合征使用不同的临床标准可用于定义syndrome.RESEARCH设计和方法-妇女参加了一项以人群为基础的前瞻性队列研究，称为健康妇女研究，并在基线后平均随访15年。代谢综合征的定义是通过世界卫生组织，国家胆固醇教育计划成人治疗小组111，和国际糖尿病基金会的临床criterions.Results -在妇女谁没有代谢综合征在基线，风险的代谢综合征的定义在多种方式变化从1.21- 2.12倍（95% CI 1.00-4.25，P < 0.05）。这些关联在很大程度上是相同的，无论用于定义代谢综合征的临床标准如何。那些在基线时报告经常和强烈愤怒、紧张或压力的人，至少在一种定义下，患代谢综合征的风险也增加（相对风险1.19-1.66 [1.00-2.39]）。结论-这些是第一个数据表明，心理社会因素预测患代谢综合征的风险。心理社会因素可能在导致代谢综合征的事件链中起因果作用。
OBJECTIVE - We evaluated whether psychosocial factors that are related to cardiovascular disease and type 2 diabetes predict prospectively the risk for the metabolic syndrome using the different clinical criteria available for defining the syndrome.RESEARCH DESIGN AND METHODS - Women were enrolled in a population-based prospective cohort study called the Healthy Women Study and were followed for an average of 15 years after baseline. Metabolic syndrome was defined via the World Health Organization, the National Cholesterol Education Program Adult Treatment Panel 111, and the International Diabetes Foundation clinical criteria.RESULTS - Among women who did not have the metabolic syndrome at the baseline, the risk for the metabolic syndrome defined in multiple ways varied from 1.21- to 2.12-fold ([95% CI 1.00-4.25], P < 0.05) for more severe depressive symptoms or very stressful life event(s). These associations were largely the same, regardless of the clinical criteria used to define the metabolic syndrome. Those who at the baseline reported feeling frequently and intensely angry, tense, or stressed also had an increased risk for developing the metabolic syndrome at least by one definition (relative risk 1.19-1.66 [1.00-2.39]).CONCLUSIONS - These are the first data to demonstrate that psychosocial factors predict the risk for developing the metabolic syndrome by multiple definitions. Psychosocial factors may play a causal role in the chain of events leading to the metabolic syndrome.